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This paper assesses the impact of Ghanaian culture on the entrepreneurial disposition of Higher National Diploma (HND) graduates of Accra Polytechnic from 2007 to 2012. Since the turn of the millennium, there has been more attention given to job creation than job seeking, especially among the youth, to address unemployment in developing countries. This is because of governments' inability to match the growing number of job seekers to job creation across the globe. One way to address this deficit in Ghana is the introduction of courses in entrepreneurship in almost all tertiary institutions, coupled with the setting up of institutions such as Ghana Youth Employment and Entrepreneurship Development Agency (GYEEDA), National Youth Employment Program (NYEP), Youth Entrepreneurship Agency (YEA), Youth Entrepreneurship Support (YES), among others. Reporting on 2015 data from Accra, the main finding was that collectivistic culture has negative effects on capital accumulation, human resource management and the urgency the unemployed graduates attached to self-employment. Therefore, this paper calls for some ways to address the issue of graduates' inability to be enterprising.