With the alarming increase in cancer diagnoses and genetic illnesses, traditional drug agents and their delivery media need to be re-evaluated to address a quickly evolving field. With newer smart materials for the controlled release of macromolecules, peptides, genetic material, etc. further complications arise, such as material performance, synthesis, functionalization and targeting, biological identity, and biocompatibility.
The book provides a comprehensive overview of the recent developments on "smart" targeting and drug delivery systems with a variety of carriers like nanoparticles, membranes, and hydrogels. It contains detailed descriptions on the recent trends in this field in the ongoing battle with catastrophic diseases like cancer. This field of research has been in its infancy and continues to face growth, and with it, further challenges and difficulties along the way toward maturity, which are accurately introduced in this book.
Contents:
- Drug Delivery Systems: Possibilities and Challenges (Ryan Spitler, Saeid Zanganeh, Tahereh Jafari, Nasser Khakpash, Mohsen Erfanzadeh, Jim Q Ho, and Nastaran Sakhaie)
- Nanoparticles in Circulation: Blood Stability (Saeid Zanganeh, Tahereh Jafari, Nasser Khakpash, Mohsen Erfanzadeh, and Jim Q Ho)
- How do Nanoparticles (NPs) Pass Barriers? (Saeid Zanganeh, Ryan Spitler, Najme Javdani, and Jim Q Ho)
- Gated Porous Materials for Biomedical Application (Félix Sancenón, Erick Yu, Elena Aznar, M Dolores Marcos, and Ramón Martínez-Máñez)
- Controlled Release from Iron Oxide Nanoparticles (Masoud Rahman)
- The Reverse of Controlled Release: Controlled Sequestration of Species and Biotoxins into Nanoparticles (NPs) (Jenifer Gómez-Pastora, Eugenio Bringas, María Lázaro-Díez, José Ramos-Vivas, and Inmaculada Ortiz)
- Membranes for Controlled Release (Vida Araban, Neda Aslankoohi, and Mohammad Raoufi)
- Controlled Released from Hydrogel (Hossein Riahinezhad, Vida Araban, and Mohammad Raoufi)
- Nano Delivery Systems (Sophie Laurent, Afsaneh Lahooti, Saeed Shanehsazzadeh, and Robert N Muller)
- Legal Framework for Protection of Pharmaceutical Trade Marks in Europe and USA (Mohammad Hossein Erfanmanesh, and Shirin Sharifzadeh)
- Future Perspective on the Smart Delivery of Biomolecules (Erick Yu, Félix Sancenón, Elena Aznar, Ramón Martínez-Máñez, María Dolores Marcos, Mohammad J Hajipour, Morteza Mahmoudi, and Pieter Stroeve)
Readership: Nanotechnologists; biomedical engineers; chemical engineers; materials scientists; biotechnology researchers; chemists; biological scientists; cell physiologists; medical scientists; gene therapists.
Morteza Mahmoudi is a biomedical investigator with a multidisciplinary background in nanoscience, bioengineering, and cardiac cellular biology. His specific research interest is controlling nano–bio interfaces to develop new nano-based therapies for prevention/treatment of life threatening conditions such as cardiomyopathy, cancer, and neurodegenerative diseases. He has a productive track record of extensive multidisciplinary collaboration, so far yielding over 160 publications in high-profile journals with more than 10,000 citations and an h-index of 48. His group has developed several approaches/assays to probe fundamental cell/molecular–nanoparticle interactions, including cell toxicity, cellular labelling, protein corona, and personalized protein corona. In addition, he introduced novel nanotechnology approaches for imaging tests, anti-biofilm bacterial applications, and probing fundamental cell/molecular–nanoparticle interactions.
Pieter Stroeve is a distinguished emeritus professor of chemical engineering at the University of California Davis, where he has taught and conducted research for 36 years. Previously he was a professor at the Department of Chemical Engineering at the University of Buffalo in New York. He also has had two postdoctoral appointments: at the Weizmann Institute of Science, Israel, and at the University of Nijmegen, the Netherlands. He obtained his Sc.D. in chemical engineering at the Massachusetts Institute of Technology and his BS in chemical engineering at the University of California Berkeley. Professor Stroeve was a visiting professor at Queensland University in Australia, the Max-Planck Institute of Polymer Science, Mainz, Germany, Wageningen University and Research Center, the Netherlands, and the Polytechnic University of Valencia in Spain.
Professor Stroeve conducts research in biological separations, nanotechnology, bio-nanotechnology, colloid and surface science, biomass conversion, image analysis, electrochemistry, and renewable energy. He has published on mass transfer with non-equilibrium chemical reactions in heterogeneous media. His focus in nanotechnology is the synthesis of nanoporous membranes, nanotubes, nanowires, nanocables, nanoparticles, and nanostructured surfaces for biosensors and sensors, nuclear reactors, nanostructured solar cells, and for molecular separations of biological molecules. In colloid and surface science, he has worked on the nanostructure of polyion-surfactant complexes, polycation–polyanion complexes, self-assembled monolayers, supported lipid bilayers, and nanoparticle–polymer composites. In renewable energy, he has conducted research on solar energy and thermoelectrics. In biomass conversion, he has worked on using pulsed electrical field to make plants more permeable to catalysts and acid molecules, by creating nanopores in the plant cell membranes, and on acid hydrolysis to make chemicals and liquid fuels. He has collaborations with scientists in Spain, Germany, the Netherlands, Iran, Japan, Taiwan, and China. He has published 300 scientific articles. Professor Stroeve has been cited over 13,000 times, and his h-index is 54. He also has won several teaching awards and is a fellow of the American Institute of Chemical Engineers
