Why does the World Health Organization (WHO) put emphasis on neglected tropical diseases (NTDs)? What are the NTDs? Are NTDs found in the United States? Is there any relationship between coronavirus disease 2019 (COVID-19) and NTDs? These are some of the questions being addressed in the book.
The aim of this textbook is to introduce a modern synthesis on human parasites of medical importance. Species of parasitic protozoa and helminths are presented in detail, from history and discovery to aspects of genomes and molecular biology, together with life cycle, therapy, drug resistance, and case studies of parasitic diseases useful to the clinicians.
Sample Chapter(s)
Preface
Chapter 1: Introduction to Parasites and Neglected Tropical Diseases
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Contents:
- Introduction of Parasites and Neglected Tropical Diseases
- Evolution of Parasites and Potential Novel Therapies from Their Genomes
- Immunity and Immunopathology of Host-Parasite Interactions
- Classification of Eukaryotes and Introduction to Protozoa
- Trypanosomiasis and Leishmaniasis by Kinetoplastid Flagellates
- Giardiasis and Trichomoniasis by Other Flagellates
- Amoebiasis and Other Infections by Amoebae and Amoeboflagellates
- Balantidiasis by a Ciliate and Blastocystis Infection by a Stramenopile
- Malaria by Apicomplexan Protozoa
- Babesiosis, Toxoplasmosis, Cryptosporidiosis and Cyclosporiasis by Other Apicomplexans
- Introduction to Flukes (Trematodes)
- Schistosomiasis (Snail Fever)
- Fascioliasis, Clonorchiasis, Opisthorchiasis and Paragonimiasis by Other Flukes
- Introduction to Tapeworms (Cestodes)
- Taeniasis, Diphyllobothriasis and Hymenolepiasis by Adult Tapeworms
- Juvenile Tapeworm Infections
- Introduction to Nematodes
- Lymphatic Filariasis (Elephantiasis)
- Loiasis (African Eye Worm), Onchocerciasis (River Blindness) and Dracunculiasis (Guinea Worm)
- Soil-Transmitted Helminth Infections
- Strongyloidiasis, Trichinellosis and Enterobiasis (Pinworm)
- Juvenile Nematode Infections
- Introduction to Arthropods
- Global Collaboration Targeting the Control and Elimination of Parasitic Diseases
Readership: Upper level undergraduates and beginning graduate students for courses in human parasitology/medical parasitology in departments of Biology/Microbiology/Zoology at colleges and universities, and in Infectious Diseases/Medicine/Microbiology and Immunology at Medical schools.
Dunne Fong is a molecular cell biologist who was trained at Princeton (under John Tyler Bonner on cellular slime mould) and Rockefeller (under Christian de Duve and Brian Poole on protein degradation, and William Trager and K P Chang on parasitic protozoa). Before Rutgers, Dunne was a faculty member at the University of Alabama at Birmingham (UAB). Dunne teaches courses in human parasitology, immunology, and cell biology at Rutgers University.
Marion M Chan is an immunologist who was trained at Sloan Kettering Institute (under Osias Stutman on cellular immunology) of Cornell University Medical College (now Weill Cornell Medical College) and UAB (under Max D Cooper where Marion made murine monoclonal antibodies to chicken CD4 and CD8, to be indispensable reagents for avian cellular immunologists). As a faculty member of the Lewis Katz School of Medicine at Temple University, Marion teaches immunology and parasitology to medical, dental, podiatric, and post-baccalaureate students at Temple University.
Marion and Dunne are collaborators on research areas including the parasitic protozoan Leishmania and the effects of dietary phytochemicals. Marion discovered the herbicide trifluralin will selectively kill the intracellular parasitic protozoan Leishmania but not its host cell (the mammalian macrophage). Marion and her graduate student identified curcumin (found in turmeric and curry) will exacerbate murine leishmaniasis, an important finding to caution the overuse of anti-inflammatory compounds as dietary supplements (they may re-activate latent infections). Marion and Dunne have received grants from the National Institutes of Health (NIH), National Science Foundation (NSF), and other sources (including National Oceanic and Atmospheric Administration, American Cancer Society, The Herb Society of America, and New Jersey Health Foundation).