Enhanced Photodynamic Therapy

Photodynamic therapy utilizes photosensitizers together with irradiating light of specific wavelengths interacting with oxygen to generate cytotoxic reactive oxygen species, in particular singlet oxygen, for clinical treatment of several malignant and non-malignant pathologies. Recently, enhanced photodynamic therapy was successfully achieved by using new light sources (i.e., light-emitting diode), novel functional nano-photosensitizers, oxygen supply and synergistic therapy. In addition, photodynamic therapy has been increasingly used in the fields of antimicrobial and antibiofilm activities. This two-volume work highlights the state-of-the-art in enhanced photodynamic therapy for clinical applications.

• Volume 1: Basics and Technical Developments:
  • Developments in Light Sources and Emission Quantifications:
    • Implementation and Uniformity Calibration of LED Array for Photodynamic Therapy (X Wang, J Xiong, X Hu and Q Li)
    • A Portable Illumination Device for Photodynamic Therapy of the Oral Cavity (J Xiong, X Wang, X Hu, Y Han and Q Li)
    • Novel Intense Pulsed Light-Photodynamic Therapy Strategy in the Treatment of Facial Actinic Keratoses Concomitant With Rosacea (S Shen, Y Cao, J Li, X Liu, Z Zhou, X Wang and P Wang)
  • Development of New Photosensitizers and Photosensitizer Monitoring or Quantification:
    • Development of a Hydrogen Peroxide-Responsive and Oxygen-Carrying Nanoemulsion for Photodynamic Therapy Against Hypoxic Tumors Using Phase Inversion Composition Method (L Hong, J Zhang, J Geng, J Qu and L Liu)
    • Binary Organic Nanoparticles with Enhanced Reactive Oxygen Species Generation Capability for Photodynamic Therapy (X Weng, Z Bao and X Wei)
    • The Application of Inorganic Optical Nanoprobes in Bacterial Infection (L Ding, L Jiang and G Liu)
    • Orthogonal Aza-BODIPY–BODIPY Dyad as Heavy-Atom Free Photosensitizer for Photo-Initiated Antibacterial Therapy (D Yang, L Sun, L Xue, X Wang, Y Hu, J Shao, L Fu and X Dong)
    • Meso-Substituted Cationic 3- and 4-N-Pyridylporphyrins and their Zn(II) Derivatives for Antibacterial Photodynamic Therapy (A G Gyulkhandanyan, M H Paronyan, A G Gyulkhandanyan, K R Ghazaryan, M V Parkhats, B M Dzhagarov, M V Korchenova, E N Lazareva, E S Tuchina, G V Gyulkhandanyan and V V Tuchin)
    • Multivariety and Multimanufacturer Drug Identification Based on Near-Infrared Spectroscopy and Recurrent Neural Network (W Zeng, Y Qiu, Y Huang, Q Sun and Z Luo)
    • A "Donor–Acceptor" Structured Semiconductor Polymer for Near Infrared Fluorescence Imaging Guided Photodynamic Therapy (B Li, T Xu, X Wang, S Zhao, B Wang, L Jiang, X Song and M Lan)
    • A Novel BODIPY-Based Nano-Photosensitizer with Aggregation-Induced Emission for Cancer Photodynamic Therapy (Y Zhang, G Li, J Li, M Wu, X Liu and J Liu)
    • Photoswitchable Semiconducting Polymer Dots with Photosensitizer Molecule and Photochromic Molecule Loading for Photodynamic Cancer Therapy (L Guo, B Xu, H Chen and Y Tang)
    • Cerium-Based Nanoparticles for Cancer Photodynamic Therapy (H Li, M Wei, X Lv, Y Hu, J Shao, X Song, D Yang, W Wang, B Li and X Dong)
    • Ultrasmall pH-Responsive Silicon Phthalocyanine Micelle for Selective Photodynamic Therapy Against Tumor (Y Zhou, W Zeng, M Wang, R Li, X Yue and Z Dai)
  • Developments in Tissue Response Monitoring for Photodynamic Therapy:
    • Three-Dimensional Imaging of Spatio-Temporal Dynamics of Small Blood Capillary Network in the Cortex Based on Optical Coherence Tomography: A Review (F Xing, J-H Lee, C Polucha and J Lee)
    • Structured Illumination Microscopy Based on Asymmetric Three-Beam Interference (L Xu, Y Zhang, S Lang, H Wang, H Hu, J Wang and Y Gong)
    • Varying of Up-Conversion Nanoparticles Luminescence from the Muscle Tissue Depth During the Compression (M Kozintseva, V Kochubey, J Konyukhova and V Tuchin)
    • High-Speed All-Optic Optical Coherence Tomography and Photoacoustic Microscopy Dual-Modal System for Microcirculation Evaluation (Y Lin, M Yu, Y Wang, Z Meng, A Li, Z He, Q Wang, J Liu, Y Yu, Y Zhao, X Zhu and Z Ma)
    • Monitoring of Time-Resolved Singlet Oxygen Luminescence at 1270 nm by an Optical Fiber Detection System (C Zhang, H Lin, Y Hu, J Sui, L Lin and B Li)
    • Application and Development of Fluorescence Probes in MINFLUX Nanoscopy (Invited Paper) (J Wang, Z Zhang, H Shen, Q Wu and M Gu)
• Volume 2: Biology and Advancements to Clinical Translation:
  • Antimicrobial Applications:
    • Antiviral Optical Techniques as a Possible Novel Approach to COVID-19 Treatment (F Moshfegh, F Khosraviani, N Moghaddasi, S F S J Limoodi and E Boluki)
    • Photokilling of Waterborne-Resistant Pathogenic Bacteria Using Cobalt-Doped Zinc Oxide Doped on Reduced Graphene Oxide Nanoparticles (A M Khan, L Pervez, J Celli, M Khattak, M Ullah, Z Shah, M M Khan, M Nadeem, S Faisal and A Nadhman)
    • Photoinactivation of Escherichia coli Using Five Photosensitizers and the Same Number of Photons (D Ortega-Zambrano, D Fuentes-López and H Mercado-Uribe)
  • Treatment Monitoring in vivo:
    • A Novel Indocyanine Green-Based Fluorescent Marker for Guiding Surgical Tumor Resection (J Ge, J D Opfermann, H Saeidi, K A Huenerberg, C D Badger, J Cha, M J Schnermann, A S Joshi and A Krieger)
  • Tissue Response Monitoring:
    • Assessment of Cerebral Oxygenation Response to Hemodialysis Using Near-Infrared Spectroscopy (NIRS): Challenges and Solutions (A Wong, L Robinson, S Soroush, A Suresh, D Yang, K Madu, M N Harhay and K Pourrezaei)
    • Automated Apoptosis Identification in Fluorescence Imaging of Nucleus Based on Histogram of Oriented Gradients of High-Frequency Wavelet Coefficients (S Liu, L Su, H Sun, T Chen, M Hu and Z Zhuang)
  • Tissue Responses Due to Secondary Effects:
    • Comparative Study on Photobiomodulation Between 630 nm and 810 nm LED in Diabetic Wound Healing Both in Vitro and in Vivo (H Zhao, T Ji, T Sun, H Liu, Y Liu, D Chen, Y Wang, Y Tan, J Zeng, H Qiu and Y Gu)
    • Noninvasive In Vivo Study of NADH Fluorescence and Its Real-Time Intrinsic Dynamical Changes: Experiments and Seven-Layered Skin Model Monte Carlo Simulations (H Hou, G Du, Y Wang, C Su, L Guo and X Chen)
    • Immune Response Induced by Hematoporphyrin Derivatives Mediated Photodynamic Therapy: Immunogenic Cell Death and Elevated Costimulatory Molecules (S Long, Y Zhao, Y Xu, Hi Li, H Zhao, D Chen, J Zeng, H Qiu, X Li and Y Gu)
  • New Techniques for Photodynamic Therapy in vivo:
    • Monitoring of Edema Progression in Permanent and Transient MCAO Model Using SS-OCT (Y Yu, Z Meng, A Li, Y Lin, J Liu, Y Ma, Y Wang and Z Ma)
    • A Miniaturized Fluorescence Imaging Device for Rapid Early Skin Cancer Detection (J Pan, Q Liu, H Sun, W Zheng, P Wang, L Wen, J Duan, Z Xuan, X Yu, S Wang, X Wang, T Zhang and W Lu)
    • In Vivo Evaluation of Laser-Induced Choroidal Neovascularization in Rats Simultaneously Using Optical Coherence Tomography and Photoacoustic Microscopy (F Du, L Gao, L Li, Q Li, F Wang, C Zhou and C Dai)
    • In Vivo Imaging and Tracking of Exosomes for Theranostics (N Ma, C Wu and Z Meng)
    • Monitoring Microenvironment of Hep G2 Cell Apoptosis Using Two-Photon Fluorescence Lifetime Imaging Microscopy (K Wang, S Tang, S Wang, F Lin, G Zou, J Qu and L Liu)
    • Three-Dimensional Quantification of Protoporphyrin IX in Photodynamic Therapy Using SFDI/DFT: A Pilot Experimental Validation (M Dan, W Song, M Liu, Y Zhang and F Gao)