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Molecular machines are complex biomolecules, proteins, nucleic acids, and carbohydrates that consume energy in order to perform specific functions. The concerted action of all those machines underlies all the activities of the living cell. To understand how such molecular machines are able to perform their function, it is necessary to identify the different moving parts and understand how they act together. Breaking new ground with these difficult problems is likely to require novel paradigms permitting a seamless integration of structural, dynamical and functional data from experiments and theory.
The goal of this volume is to provide an introduction to the world of biological molecular machines to a broad audience of students and researchers in biosciences. Each chapter is written by leading experts to cover results from cutting-edge research, while remaining broadly accessible. The volume presents the current state of knowledge for several important systems, ranging from polymerases, the ribosome, chaperonins, the chromatophore, kinases, actin and myosin, membrane transporters, and voltage-gated ion channels, thus giving students and researches in biosciences a pedagogically integrated picture of this exciting and rapidly expanding field.
Sample Chapter(s)
Chapter 1: Molecular Behavior in Biological Cells (1,852 KB)
Contents:
- Molecular Behavior in Biological Cells: The Bacterial Cytoplasm as aModel System (Adrian H Elcock and Andrew S Thomas [University of Iowa, USA])
- The Light-Harvesting Apparatus in Purple Photosynthetic Bacteria: Introduction to a Quantum Biological Device (Johan Strümpfer, Jen Hsin, Melih Şener, Danielle Chandler and Klaus Schulten [University of Illinois at Urbana-Champaign, USA])
- DNA Polymerases: Structure, Function and Modeling (Tamar Schlick [New York University, USA])
- Information Processing by Nanomachines: Decoding by the Ribosome (Karissa Y Sanbonmatsu [Los Alamos National Laboratory, USA], Scott C Blanchard [Weill Cornell Medical College, USA] and Paul C Whitford [Los Alamos National Laboratory, USA])
- Chaperonins: The Machines Which Fold Proteins (Del Lucent [Center for Materials Science and Engineering, Australia], Martin C Stumpe and Vijay S Pande [Stanford University, USA])
- Muscle and Myosin (Ronald S Rock, Jr [The University of Chicago, USA])
- Protein Kinases: Phosphorylation Machines (Elaine E Thompson, Susan S Taylor and J Andrew McCammon [University of California at San Diego, USA])
- Computational Studies of Na+/H+ Antiporter: Structure, Dynamics and Function (Assaf Ganoth, Raphael Alhadeff and Isaiah T Arkin [The Hebrew University of Jerusalem, Israel])
- Membrane Transporters — Molecular Machines Coupling Cellular Energy to Vectorial Transport Across the Membrane (Zhijian Huang, Saher A Shaikh, Po-Chao Wen, Giray Enkavi, Jing Li and Emad Tajkhorshid [University of Illinois at Urbana-Champaign, USA])
- ABC Transporters (E P Coll and D P Tielema [University of Calgary, Canada])
- Sodium-coupled Secondary Transporters: Insights from Structure-basedComputations (Elia Zomot, Ahmet Bakan, Indira H Shrivastava, Jason DeChancie,Timothy R Lezon and Ivet Bahar [University of Pittsburgh, USA])
- Voltage-Gated Ion Channels: The Machines Responsible for the Nerve Impulse (Benoît Roux and Francisco Bezanilla [The University of Chicago, USA])
- Voltage-Gated Channels and the Heart (Jonathan R Silva [Washington University School of Medicine, USA] and Yoram Rudy [Washington University in St Louis, USA])
Readership: Biochemists, students and researchers in biological sciences.
