Multidisciplinary Management of Gastrointestinal Cancers

The following sections are included:

• Contents
• Preface
• List of Contributors

The following sections are included:

• Introduction
• Colon Cancer
• Esophageal Cancer
• Gastric Cancer
• Pancreatic Cancer
• Cholangiocarcinoma
• Gallbladder Cancer
• Small Intestine Cancers
• References

Recent reports of efficacy of immune therapies in solid tumors other than melanoma and renal cell carcinoma have raised enthusiasm for testing immunotherapy in gastrointestinal (GI) malignancies. Strategies under development include antibodies and related molecules that mediate cellular cytotoxicity, vaccines intended to activate tumor-specific T cell and antibody responses, adoptive transfer of natural killer (NK) cells, tumor infiltrating lymphocytes, and chimeric antigen receptor T cells, and immunomodulatory drugs such as checkpoint blocking antibodies. Thus far, benefit has been modest although insights from these studies have provided new directions for testing. We will review the current status of the various immunotherapy approaches undergoing testing in GI malignancies.

The following sections are included:

• Introduction
• Ablative Therapies for Barrett's Esophagus
• Endoscopic Treatment of Early Esophageal Cancer
• Conclusion
• References

The following sections are included:

• Esophageal Cancer
• Gastric Cancer
• Unanswered Questions and Ongoing Studies
• References

The following sections are included:

• Introduction
• Staging
• Tumor Classification
• Principles of Surgical Resection
• Surgical Approaches
• Oncologic Outcomes After Surgical Treatment
• Comparative Studies of Surgical Approaches
• Conclusions
• References

The following sections are included:

• Introduction
• Differences in Epidemiology Between the East and the West
• Localized Gastric Cancer
• Unresectable or Metastatic Gastric Cancer
• Conclusions
• References

The following sections are included:

• Introduction
• Risk Factors
• Genetics of Esophageal and Gastric Cancer
• Cytotoxic Chemotherapy
• Targeted Therapy
• Summary
• References

The following sections are included:

• Background/Introduction
• Anatomy/Pathophysiology
• Appendiceal Neoplasms
• Colorectal Carcinoma
• Gastric Carcinoma
• Conclusions
• References

The following sections are included:

• Introduction
• Clinical Findings
• Multimodality Imaging and Diagnosis
• Staging
• Surveillance
• Differential Diagnosis
• Conclusion
• References

The following sections are included:

• Introduction
• Rationale for Adjuvant Therapy for Resectable or Borderline Resectable Disease
• Resectable Patients
• Borderline Resectable Patients
• Unresectable Disease
• Metastatic Pancreatic Cancer
• Radiation Treatment Planning and Techniques
• Radiation Therapy Treatment Modalities
• Conclusions
• References

The following sections are included:

• Introduction
• Evolution of Pancreatic Cancer Surgery
• Evolution of Minimally Invasive Pancreas Surgery
• Robotic Surgery
• Conclusions
• References

The following sections are included:

• Introduction
• Pathology
• Etiology
• Genomics of Pancreatic Cancer
• Clinical Presentation
• Diagnostic Work-Up
• Clinical Staging of Pancreatic Cancer
• Systemic Therapy
• Future Directions in Systemic Therapy
• Conclusions
• References

The following sections are included:

• Introduction
• Cytotoxic Chemotherapy
• Biologic Therapies
• Maintenance Therapy and Duration of Therapy
• Emerging Treatments: Immunotherapy
• Conclusions
• References

The following sections are included:

• Introduction
• Local and Regional Staging
• Surgical Therapy
• Adjuvant and Neuoadjuvant Therapy
• Role of Biologic Agents in Rectal Cancer
• Summary and Authors' Recommendations by Clinical Stage
• References

The following sections are included:

• Introduction
• The Role of Fluoropyrimidines
• Role of Oxaliplatin in Adjuvant Chemotherapy
• The Role of Irinotecan in Adjuvant Chemotherapy
• The Role of Biologics in Adjuvant Therapy
• Stage II Colon Cancer
• Treatment Considerations in the Elderly
• Optimal Duration of Adjuvant Chemotherapy
• Risk Stratification Based on High-Risk Prognostic Features and Predictive Molecular Biomarkers
• Pharmacoeconomic Considerations in Adjuvant Chemotherapy
• On-Going Phase III Adjuvant Studies
• Future Directions
• Conclusion
• References

The following sections are included:

• Introduction
• Surgical Resection or Liver Transplantation for Early HCC
• Tumor Biology
• Local Therapy
• Regional Therapy
• Systemic Therapy
• Conclusions
• References

The following sections are included:

• Introduction
• Anatomy and Classification
• Diagnosis
• Staging
• Surgical Resection
• Systemic Chemotherapy
• Future Directions
• References

The following sections are included:

• Introduction
• Epidemiology
• The Cell of Origin
• Tumor Biology
• Pathology, Staging, and Prognosis
• Clinical Features
• Familial Neuroendocrine Syndromes
• Sporadic GEP-NETs
• Diagnosis
• Follow-Up
• Surgical Approach to GEP-NETs
• Systemic Treatment of Metastatic GEP-NETs
• Management of Liver Metastases
• Conclusions
• References

The following sections are included:

• Introduction
• Clinical Presentation and Diagnosis
• Treatment
• Resistance to Imatinib Treatment
• Conclusions
• References

The following sections are included:

• Introduction
• Epidemiology
• Clinical Presentation
• Diagnosis
• Adenocarcinoma
• Carcinoid Tumors
• Sarcomas
• Intestinal Lymphomas
• References

The following sections are included:

• Introduction
• General Complications of Gastrointestinal Cancers
• Metastatic Complications of Gastrointestinal Malignancies
• Treatment Related Complications of Gastrointestinal Malignancies
• Supportive Care by Cancer Site
• References

The following sections is included:

• Index