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A review of risk assessment research in the context of extreme weather events (EWE) reveals that conceptual approaches addressing the risk of critical infrastructures (CI) focus primarily on single components and factors of CI that are at risk. The objective of the paper is to introduce an integrative framework that considers the complex set-up of CI and links it to newer conceptualizations of risk management and adaptation. Drawing on existing risk and resilience approaches, this paper brings together aspects of the engineering community, which currently dominate CI-related research, and of disaster risk reduction research communities, resilience and adaptation research in the context of natural hazards. The paper thereby presents an adapted approach that particularly addresses interdependencies of infrastructures as well as future dynamics. The risk concept applied is based on the IPCC framework and considers the manifold impacts of CI failures upon society, economy and environment. Recommendations for risk management regimes are thereby formulated in the context of EWE. Based on a more holistic socio-ecological systems’ perspective, the approach covers the dynamic transformation of a system’s resilience state. The framework provides a tool and concept to improve the understanding of the multitude factors determining the risks of EWE for CI. Additional research is required for the further operationalization of the conceptual framework, such as the development of indicators, in order to enable the practical implementation for the support of risk management concepts.