We review the results of our current research on quantum engineering which include the theory, modeling and simulations of quantum devices for potential applications to threat reduction and homeland security. In particular, we discuss: (i) scalable solid-state quantum computation with qubits based on (a) nuclear spins of impurity atoms in solids, (b) superconducting junctions, and (c) unpaired electron spins of spin radicals in self-assembled organic materials; (ii) quantum neural devices; (iii) quantum annealing; (iv) novel magnetic memory devices based on magnetic tunneling junctions with large tunneling magnetoresistance; (v) terahertz detectors based on microcantilever as a light pressure sensor; (vi) BEC based interferometers; (vii) quantum microscopes with a single-spin resolution based on (a) a magnetic resonant force microscopy and (b) an optically detected magnetic resonance; and (viii) novel approach for suppression of fluctuations in free space high-speed optical communication. Finally, we describe the similarities between the behavior of cross sections in reactions with heavy nuclei in the regions of strongly overlapped resonances and electron conductivity in semiconductor heterostructures.