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The increasingly heterogeneous demographic profile of drug abusers in Singapore requires a multifaceted approach to intervention. Singapore invests heavily in evidence-informed, differentiated rehabilitation pathways to ensure that interventions are targeted to the appropriate level of risk, needs and responsivity of drug abusers. The Transformational Environment was introduced in the Drug Rehabilitation Centre (DRC) to create a safe and supportive setting designed to facilitate rehabilitation, reintegration and long-term desistance. This chapter illustrates how the DRC implemented the Transformational Environment by enhancing people, processes and programmes, and provides suggestions to common challenges faced when working with drug abusers.