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Photodynamic therapy against achromic M6 melanocytes: phototoxicity of lipophilic axially substituted aluminum phthalocyanines and hexadecahalogenated zinc phthalocyanines

Laboratoire AM3: Activation, Mécanismes, Modélisation Moléculaire, Faculté des Sciences Saint Jérôme, F-13397 Marseille Cédex 20, France

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MARIE-JEANNE RICHARD

Laboratoire de Biochimie C, Centre Hospitalier Universitaire A. Michallon, BP 217X, F-38043 Grenoble Cédex, France

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, and

MICHEL JULLIARD

Laboratoire AM3: Activation, Mécanismes, Modélisation Moléculaire, Faculté des Sciences Saint Jérôme, F-13397 Marseille Cédex 20, France

Corresponding author, Laboratoire AM3 ESA CNRS 6009, Faculté des Sciences Saint Jérôme, F-13397 Marseille Cédex 20, France.

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https://doi.org/10.1002/jpp.343Cited by:13 (Source: Crossref)

Abstract

Lipophilic and axially substituted tri-n-hexylsiloxy aluminum phthalocyanine and cholesteryloxy diphenylsiloxy aluminum phthalocyanine were synthesized and assayed in PDT against M6 melanocytes. In the conditions used (λ > 480 nm, 10 mW cm^-2, egg-yolk lecithin or cremophor EL formulation) they both exhibited a higher photodynamic effect than chloroaluminum phthalocyanine. They displayed 2% to 3.5% cell viability at 10^-5M dose for 20 min irradiation. Hexadecafluoro zinc phthalocyanine was synthesized to increase the lipophilicity of zinc phthalocyanine, hexadecachloro zinc phthalocyanine was also included because it would theoretically enhance the phototoxicity. In all the delivery systems used, their photodynamic effect against M6 melanocytes was lower in comparison with zinc phthalocyanine and axially substituted aluminum phthalocyanines. A 2 h irradiation treatment with 3 × 10^-6M hexadecafluoro zinc phthalocyanine and 10^-5 M hexadecachloro zinc phthalocyanine led to 60% and 15% cell viability respectively. In all cases, the cell killing effect was light-and dose-dependent and was higher in cremophor EL micelles than in the egg-yolk lecithin formulation.

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