The Impact of Structural Proteomics on the Prediction of Protein– Protein Interactions

The following sections are included:

• Introduction

• Structure-based Prediction of Protein Interactions

  • Prediction of Binding Energies and Hot Spot Residues

  • Protein Design and Homology Modeling as Tools to Modify Protein Interactions

  • Prediction of Protein Interactions as Tools for Analyzing Protein Networks

• Prediction of Protein Interactions Using Homology Modeling: Factors Influencing Its Success

  • The Interaction Type and the Interface

  • Structure-based Sequence Alignments

  • Structural Inspection of Domains and Sequences

  • Template Structures

• Obtaining the Right Reference for Deciding if Two Proteins Interact

• Conclusion

• Acknowledgements

• References