Cryo-Electron Microscopy in the Era of Structural Proteomics

The following sections are included:

• Summary

• Background

• Cryo-EM Today

• Suitability of Cryo-EM for The Analysis of Multi-Subunit Protein Complexes

• Particle Heterogeneity: in silico Fractionation and Implications for Dynamics

• "Less Low Throughput" Techniques in Cryo-EM

• The Hybrid Approach to Leveraging Resolution

• Discrepancies Between Crystal Structures and Cryo-EM Structures

• X-ray Crystallography and Cryo-EM are Mutual Complements

• Perspective

• Acknowledgments

• References

• Appendix

• References (for Appendix)