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Breviscapine: A Review on its Phytochemistry, Pharmacokinetics and Therapeutic Effects

Luan Wen

School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, P. R. China

These authors contributed equally to this work.

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Ting He

School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, P. R. China

These authors contributed equally to this work.

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AXiang Yu

School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, P. R. China

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Siqi Sun

School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, P. R. China

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Xiang Li

School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, P. R. China

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Jing Wei

School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, P. R. China

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Ruolan Song

School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, P. R. China

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Xin Yan

School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, P. R. China

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Ruiwen Li

School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, P. R. China

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Xueyang Ren

School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, P. R. China

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Yu Wang

School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, P. R. China

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Xiaoyun Liu

School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, P. R. China

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Ying Dong

School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, P. R. China

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Xueyan Fu

School of Pharmacy, Ningxia Medical University, Ningxia 750004, P. R. China

Key Laboratory of Hui Ethnic Medicine Modernization, Ministry of Education, Ningxia 750004, P. R. China

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, and

Gaimei She

School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, P. R. China

E-mail Address: shegaimei@126.com

Correspondence to: Prof. Gaimei She, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Advanced Education Park, Fangshan District, Beijing 102488, P. R. China. Tel: (+86) 10-8473-8628.

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https://doi.org/10.1142/S0192415X21500646Cited by:36 (Source: Crossref)

Abstract

Breviscapine is one of the extracts of several flavonoids of Erigeron breviscapus. Scutellarin is the main active component of breviscapine, and the qualitative or quantitative criteria as well. Scutellarin and its analogs share a similar skeleton of the flavonoids. Breviscapine has been widely used in the treatment of cerebral infarction and its sequelae, cerebral thrombus, coronary heart disease (CHD), and angina pectoris. Breviscapine has a broad spectrum of pharmacological activities, such as increasing blood flow, improving microcirculation, dilating blood vessels, decreasing blood viscosity, promoting fibrinolysis, inhibiting platelet aggregation, and thrombosis formation, etc. In addition, breviscapine and its analogs have significant value for drug research and development because of the superiority of those significant bioactivities. Furthermore, an increasing number of pharmacokinetic studies have explored the mechanism of scutellarin and its analogs. To provide a comprehensive understanding of the current research on breviscapine, scutellarin, and the analogs, the structural features, distribution situation, preparation method, content determination method, clinical applications, pharmacological action as well as pharmacokinetics are summarized in the present review.

Keywords:

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