Research PapersNo Access

A NEW SIMPLE CORRELATION FOR CALCULATING SOLUBILITY OF DRUGS IN SUPERCRITICAL CARBON DIOXIDE

ALI ZEINOLABEDINI HEZAVE

Islamic Azad University, Dashtestan Branch, Borazjan, Iran

Corresponding author.

Search for more papers by this author

and

MOSTAFA LASHKARBOLOOKI

Islamic Azad University, Dashtestan Branch, Borazjan, Iran

Search for more papers by this author

https://doi.org/10.1142/S0219633613500624Cited by:3 (Source: Crossref)

Abstract

During the past 20 years, supercritical fluid (SCF) based technologies have been gaining an increasing attention through the academic and industrial communities due to its advantages. One of the most important parameter for any supercritical-based technologies is the knowledge of the solute solubility at different pressures and temperatures. But, due to several concerns e.g. time and expense, measuring the solubility of all compounds in wide ranges of temperature and pressure is not possible. Respect to this, a new empirical correlation with four fitting parameters has been proposed to correlate the solubility of pharmaceuticals in different temperatures and pressures. The obtained results compared with four widely used density based correlations including Mendez-Santiago and Teja (MST), Bartle et al., Chrastil, Kumar and Johnston (KJ) revealed rather good capability of the proposed simple correlation for predicting the solubility of solutes in supercritical carbon dioxide (SC-CO₂). At last, the obtained results compared with the results of three Equations of State (EoS's) with three different mixing rules.

Keywords:

References

M. Soares da Silvaet al., Int. J. Pharmaceutics. 416(1), 61 (2011). Crossref, Web of Science, Google Scholar
A. Ritaet al., Int. J. Pharmaceutics. 308(2), 168 (2006). Crossref, Web of Science, Google Scholar
I. Papamichail, V. Louli and K. Magoulas, The. J. Supercrit. Fluids. 18(3), 213 (2000). Crossref, Web of Science, Google Scholar
H. Rajaeiet al., Korean. J. Chem. Eng. 30(4), 842 (2013). Crossref, Web of Science, Google Scholar
Y.-N. Leeet al., Separation. Purification. Technol. 54(1), 130 (2007). Crossref, Web of Science, Google Scholar
F. Esmaeilzadeh and I. Goodarznia , J. Chem. Eng. Data. 50 , 49 ( 2005 ) . Crossref, Web of Science, Google Scholar
Ch.-Sh. Su and Y.-P. Chen , J. Supercrit. Fluids. 43 , 438 ( 2008 ) . Crossref, Web of Science, Google Scholar
S. J. Macnaughton et al. , J. Chem. Eng. Data. 41 , 1083 ( 1996 ) . Crossref, Web of Science, Google Scholar
A. Z. Hezave , S. Aftab and F. Esmaeilzadeh , J. Supercrit. Fluids. 68 , 39 ( 2012 ) . Crossref, Web of Science, Google Scholar
A. Z. Hezave , M. H. Khademi and F. Esmaeilzadeh , Fluid. Phase. Equilibria. 313 , 140 ( 2012 ) . Crossref, Web of Science, Google Scholar
A. Z. Hezave and F. Esmaeilzadeh, J. Chem. Eng. Data. 57(6), 1659 (2012). Crossref, Web of Science, Google Scholar
A. Z. Hezave and F. Esmaeilzadeh , J. Dispersion. Sci. Technol. 338 , 1106 ( 2012 ) . Crossref, Web of Science, Google Scholar
A. Z. Hezave and F. Esmaeilzadeh, J. Dispersion. Sci. Technol. 33(7), 990 (2012). Crossref, Web of Science, Google Scholar
A. Z. Hezave and F. Esmaeilzadeh, J. Dispersion. Sci. Technol. 33(10), 1419 (2012). Crossref, Web of Science, Google Scholar
A. Z. Hezave and F. Esmaeilzadeh , J. Supercrit. Fluids. 52 , 84 ( 2010 ) . Crossref, Web of Science, Google Scholar
A. Z. Hezave and F. Esmaeilzadeh , J. Aerosol. Sci. 41 , 1090 ( 2010 ) . Crossref, Web of Science, Google Scholar
A. Z. Hezave , S. Aftab and F. Esmaeilzadeh , J. Aerosol. Sci. 41 , 821 ( 2010 ) . Crossref, Web of Science, Google Scholar
A. Z. Hezave and F. Esmaeilzadeh , J. Crystal. Growth. 312 , 3373 ( 2010 ) . Crossref, Web of Science, Google Scholar
A. Z. Hezave , S. Aftab and F. Esmaeilzadeh , J. Supercrit. Fluids. 55 , 316 ( 2010 ) . Crossref, Web of Science, Google Scholar
J. Jung and M. Perrut , J. Supercrit. Fluids. 20 , 179 ( 2001 ) . Crossref, Web of Science, Google Scholar
M. Christov and R. Dohrn , Fluid. Phase. Equilibria. 202 , 153 ( 2002 ) . Crossref, Web of Science, Google Scholar
P. T. V. Rosa , M. Angela and A. Meireles , J. Supercrit. Fluids. 34 , 109 ( 2005 ) . Crossref, Web of Science, Google Scholar
Ö Güçlü-Üstündağ and F. Temelli , J. Supercrit. Fluids. 36 , 1 ( 2005 ) . Crossref, Web of Science, Google Scholar
D. Prajapati and M. Gohain , Tetrahedron 60 , 815 ( 2004 ) . Crossref, Web of Science, Google Scholar
A. Jouyban , H. K. Chan and N. R. Foster , J. Supercrit. Fluids. 24 , 19 ( 2002 ) . Crossref, Web of Science, Google Scholar
H. Yang and C. Zhong , J. Supercrit. Fluids. 33 , 99 ( 2005 ) . Crossref, Web of Science, Google Scholar
S. Guha and G. Madras , Fluid. Phase. Equilibria. 187 , 255 ( 2001 ) . Crossref, Web of Science, Google Scholar
J. M'endez-Santiago and A. S. Teja , Fluid. Phase. Equilibria. 158 , 501 ( 1999 ) . Crossref, Web of Science, Google Scholar
K. D. Bartle et al. , J. Phys. Chem. Ref. Data. 20 , 713 ( 1991 ) . Crossref, Web of Science, Google Scholar
J. Chrastil, J. Phys. Chem. 86(15), 3016 (1982). Crossref, Web of Science, Google Scholar
S. K. Kumar and K. P. Johnston , J. Supercrit. Fluids. 1 , 15 ( 1988 ) . Crossref, Google Scholar
S. Ismadji and S. K. Bhatia , J. Supercrit. Fluids. 27 , 1 ( 2003 ) . Crossref, Web of Science, Google Scholar
G. Madras , C. Kulkarni and J. Modak , Fluid. Phase. Equilibria. 209 , 207 ( 2003 ) . Crossref, Web of Science, Google Scholar
A. Sane et al. , J. Supercrit. Fluids. 28 , 277 ( 2003 ) . Crossref, Web of Science, Google Scholar
U. Kopcak and R. S. Mohamed , J. Supercrit. Fluids. 34 , 209 ( 2005 ) . Crossref, Web of Science, Google Scholar
Jha , S. Kumar and G. Madras , Fluid. Phase. Equilibria. 238 , 174 ( 2005 ) . Crossref, Web of Science, Google Scholar
M. R. Housaindokht and M. R. Bozorgmehr , J. Supercrit. Fluids. 43 , 390 ( 2008 ) . Crossref, Web of Science, Google Scholar
P. Coimbra , C. M. M. Duarte and H. C. de Sousa , Fluid. Phase. Equilibria. 239 , 188 ( 2006 ) . Crossref, Web of Science, Google Scholar
W. G. Chapman et al. , Fluid. Phase. Equilibria. 52 , 31 ( 1989 ) . Crossref, Web of Science, Google Scholar
D. S. H. Wong and S. I. Sandler , AIChE. J. 38 , 671 ( 1992 ) . Crossref, Web of Science, Google Scholar
M. Hojjatiet al., The. J. Supercrit. Fluids. 50(3), 203 (2009). Crossref, Web of Science, Google Scholar
M. Hojjati et al. , The. J. Supercrit. Fluids. 41 , 187 ( 2007 ) . Crossref, Web of Science, Google Scholar
D. L. Sparks , R. Hernandez and L. A. Estevez , Chem. Eng. Sci. 63 , 4292 ( 2008 ) . Crossref, Web of Science, Google Scholar
M. Asghari-Khiavi , Y. Yamini and M. A. Farajzadeh , J. Supercrit. Fluids. 30 , 111 ( 2004 ) . Crossref, Web of Science, Google Scholar
Y. Yamini , J. Arab and M. Asghari-khiavi , J. Pharmaceutical. Biomedi. Analy. 32 , 181 ( 2003 ) . Crossref, Web of Science, Google Scholar
A. R. C. Duarte et al. , J. Chem. Eng. Data. 49 , 449 ( 2004 ) . Crossref, Web of Science, Google Scholar
M. Mirzajanzadeh, F. Zabihi and M. Ardjmand, J. Chem. Eng. 7(4), 42 (2010). Google Scholar
B. Ghalami-Choobar, A. Ghiami-Shomami and P. Nikparsa, J. Theoret. Comput. Chem. 11(2), 283 (2012). Link, Web of Science, Google Scholar
X. Zhang, X. Han and W. Xu, J. Theoret. Comput. Chem. 10(4), 483 (2011). Link, Web of Science, Google Scholar
M. Lashkarbolooki et al. , J. Supercrit. Fluids. 75 , 144 ( 2013 ) . Crossref, Web of Science, Google Scholar
M. Lashkarbolooki, A. Zeinolabedini Hezave and S. Ayatollahi, Fluid. Phase. Equilibria. 324(25), 102 (2012). Crossref, Web of Science, Google Scholar
http://www.doc.ic.ac.uk/~nd/surprise_96/journal/vol4/tcw2/report.html . Google Scholar
http://www.cs.cmu.edu/Groups/AI/html/faqs/ai/genetic/part2/faq-doc-2.html . Google Scholar
http://www.ai-junkie.com/ga/intro/gat1.html . Google Scholar
O. Pfohl et al. , High-Pressure Fluid-Phase Equilibria Containing Supercritical Fluids , 8th Int. Conf. Properties and Phase Equilibria for Product and Process Design ( 1998 ) . Google Scholar
I. Ashour et al. , Fluid. Phase. Equilibria. 167 , 41 ( 2000 ) . Crossref, Web of Science, Google Scholar