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Molecular pathways in cancer response to photodynamic therapy

Valentina Rapozzi

Department of Medicine, University of Udine, P.le Kolbe 4, Udine, 33100, Italy

E-mail Address: valentina.rapozzi@uniud.it

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Francesca D’Este

Department of Medicine, University of Udine, P.le Kolbe 4, Udine, 33100, Italy

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, and

Luigi E. Xodo

Department of Medicine, University of Udine, P.le Kolbe 4, Udine, 33100, Italy

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https://doi.org/10.1142/S1088424619300064Cited by:15 (Source: Crossref)

Abstract

This minireview describes the complexity of the molecular mechanisms involved in the tumor response to photodynamic treatment (PDT). Different aspects of reactive oxygen (ROS) and nitrogen species (RNS) induced by PDT will be examined. In particular, we will discuss the effect of ROS and RNS on cell compartments and the main mechanisms of cell death induced by the treatment. Moreover, we will also examine host defense mechanisms as well as resistance to PDT.

This paper is part of the 2019 Women in Porphyrin Science special issue.

Keywords:

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