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Research ArticlesNo Access

GROWTH AND GLOBAL GENE EXPRESSION OF EUCARYOTIC CELLS

VLADIMIR P. ZHDANOV

VLADIMIR P. ZHDANOV

Department of Applied Physics, Chalmers University of Technology, S-412 96 Göteborg, Sweden

Boreskov Institute of Catalysis, Russian Academy of Sciences, Novosibirsk 630090, Russia

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https://doi.org/10.1142/S1793048011001233Cited by:1 (Source: Crossref)

Abstract

We present a kinetic model describing the growth of eukaryotic cells or, more specifically, the dependence of the cell volume on time in terms of the global interplay of the mRNA and protein synthesis and degradation and lipid synthesis. Addressing two long-standing questions in this interdisciplinary field, we explain why the average protein concentration in growing cells is nearly constant and the growth can accurately be fitted by using a bilinear or exponential function.

Keywords:

PACS: 87.16.-b

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Journal cover image

Vol. 06, No. 01n02

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History

Received 22 August 2010

Revised 26 November 2010

Accepted 8 December 2010

Keywords