World Scientific
  • Search
    Quick Search in Journals
    Access type:
    Quick Search anywhere
    Access type:
    Advanced Search
  • My Cart
  •   
Skip main navigation
Close Drawer MenuOpen Drawer Menu

Cookies Notification

We use cookies on this site to enhance your user experience. By continuing to browse the site, you consent to the use of our cookies. Learn More
×

Our site uses Javascript to enchance its usability.You can disable your ad blocker or whitelist our website www.worldscientific.com to view the full content.

Select your blocker:

Adblock Plus Instructions

  1. Click the AdBlock Plus icon in the extension bar
  2. Click the blue power button
  3. Click refresh
Our website is made possible by displaying certain online content using javascript.
In order to view the full content, please disable your ad blocker or whitelist our website www.worldscientific.com.

System Upgrade on Tue, Oct 25th, 2022 at 2am (EDT)

Existing users will be able to log into the site and access content. However, E-commerce and registration of new users may not be available for up to 12 hours.
For online purchase, please visit us again. Contact us at [email protected] for any enquiries.
BRIEF REPORTNo Access

Facile and Large-Scale Synthesis of Graphene Quantum Dots Functionalized with Morpholine for Selective Targeting and Imaging of Lysosome

    https://doi.org/10.1142/S1793292021501137Cited by:1 (Source: Crossref)
    Previous
    Next

    Abstract

    The lack of targeting selection to lysosome limits the application of graphene quantum dots (GQDs) in the diagnosis and treatment of lysosome-related disease. In this study, we developed a facile, environmentally friendly and large-scale method to prepare N-aminomorpholine (Am)-modified GQDs (Am-GQDs) via a simple hydrothermal method. The physicochemical, optical, biocompatible and targeted imaging properties were evaluated systematically. The results indicated that the synthesized Am-GQDs had a uniform size distribution and the size was around 2nm. In addition, the synthesized Am-GQDs had excellent optical properties, fluorescent stability, and good biocompatibility. More importantly, they can selectively target and image lysosome in a relatively short coculture time with cells, demonstrating their application potential in the diagnosis and treatment of lysosomal-related diseases.

    References

    • 1. S. Bak, D. Kim and H. Lee , Curr. Appl. Phys. 16, 1192 (2016). Crossref, ISI, Google Scholar
    • 2. W. Chen, G. Lv, W. Hu, D. Li, S. Chen and Z. Dai , Nano Rev. 7, 157 (2018). Google Scholar
    • 3. M. Li, T. Chen, J. J. Gooding and J. Liu , ACS Sens. 4, 1732 (2019). Crossref, ISI, Google Scholar
    • 4. D. Wang, Y. Zhang, M. Zhai, Y. Huang, H. Li, X. Liu, P. Gong, Z. Liu and J. You , ChemNanoMat 7, 71 (2021). Crossref, ISI, Google Scholar
    • 5. S. Chung, R. A. Revia and M. Zhang , Adv. Mater. 33 1904362 (2021). Crossref, ISI, Google Scholar
    • 6. J. Peng, P. Gong, S. Han, L. Kong, X. Ge, B. Wang, L. Guo, Z. Liu and J. You , Chem. Eng. J. 391, 123619 (2019). Crossref, ISI, Google Scholar
    • 7. H. Lu, W. Li, H. Dong and M. Wei , Small 15, 1902136 (2019). Crossref, ISI, Google Scholar
    • 8. J. P. Luzio, P. R. Pryor and N. A. Bright , Nat. Rev. Mol. Cell Biol. 8, 622 (2007). Crossref, ISI, Google Scholar
    • 9. W. W. Y. Yim and N. Mizushima , Cell Discov. 6, 6 (2020). Crossref, ISI, Google Scholar
    • 10. P. Boya , Antioxid. Redox Signal. 17, 766 (2012). Crossref, ISI, Google Scholar
    • 11. I. Sambri and A. Fraldi , Adv. Clin.Neurosci.Rehabil. 15, 13 (2015). Google Scholar
    • 12. Y. Han, M. Li, F. Qiu, M. Zhang and Y. H. Zhang , Nat. Commun. 8, 1307 (2017). Crossref, ISI, Google Scholar
    • 13. Z. Wang, D. Chen, B. Gu, B. Gao, Z. Liu, Y. Yang, Q. Guo, X. Zheng and G. Wang , Diam. Relat. Mater. 104, 107749 (2020). Crossref, ISI, Google Scholar
    • 14. M. K. Kumawat, M. Thakur, R. B. Gurung and R. Srivastava , Sci. Rep. 7, 15858 (2017). Crossref, ISI, Google Scholar
    • 15. C. Wang, C. Wu, X. Zhou, T. Han, X. Xin, J. Wu, J. Zhang and S. Guo , Sci. Rep. 3, 2852 (2013). Crossref, ISI, Google Scholar
    • 16. J. H. Liu, R. S. Li, B. Yuan, J. Wang, Y. F. Li and C. Z. Huang , Nanoscale 10, 17402 (2018). Crossref, ISI, Google Scholar
    • 17. Z. Fan, Y. Nie, Y. Wei, J. Zhao, X. Liao and J. Zhang , Mater. Sci. Eng. C 103, 109824 (2019). Crossref, ISI, Google Scholar
    • 18. Z. Q. Zhang, W. J. Yao, L. L. Qiao, X. Yang, J. Shi and M. X. Zhao , The journal is International Journal of Nanomedicine 15, 1611 (2020). ISI, Google Scholar
    • 19. L. Hu, Y. Sun, S. Li, X. Wang, K. Hu, L. Wang, X. Liang and Y. Wu , Carbon 67, 508 (2014). Crossref, ISI, Google Scholar
    • 20. L. Wang, Y. Wang, T. Xu, H. Liao, C. Yao, Y. Liu, Z. Li, Z. Chen, D. Pan and L. Sun , Nat. Commun. 5, 5357 (2014). Crossref, ISI, Google Scholar
    • 21. A. Durazzo, J. Kiefer, M. Lucarini, E. Camilli, S. Marconi, P. Gabrielli, A. Aguzzi, L. Gambelli, S. Lisciani and L. Marletta , Sustainability 10, 4112 (2018). Crossref, ISI, Google Scholar
    • 22. R. Zhang, Z. Huang, C. Li, Y. Zuo and Y. Zhou , Appl. Surf. Sci. 475, 953 (2019). Crossref, ISI, Google Scholar
    • 23. D. V. Vasava and S. K. Patel , Int. Lett. Chem. Phys. Astron. 70, 48 (2016). Crossref, Google Scholar
    • 24. Y. Xu, H. Bai, G. Lu, C. Li and G. Shi , J. Am. Chem. Soc. 130, 5856 (2008). Crossref, ISI, Google Scholar
    • 25. B. Mehrdad-Vahdati, S. Pourhashem, M. Sedghi, Z. Vaezi, B. Shojaedin-Givi, A. Rashidi and H. Naderi-Manesh , Toxicol. In Vitro 61, 104649 (2019). Crossref, ISI, Google Scholar
    • 26. M. J. Youh, M. Y. Jiang, M. C. Chung, H. C. Tai and Y. Y. Li , Inorg. Chem. Commun. 119, 108061 (2020). Crossref, ISI, Google Scholar
    • 27. D. Huang, H. Zhou, Y. Wu, T. Wang, L. Sun, P. Gao, Y. Sun, H. Huang, G. Zhou and J. Hu , Carbon 142, 673 (2019). Crossref, ISI, Google Scholar
    • 28. D. L. Silva, J. L. E. Campos, T. F. D. Fernandes, J. N. Rocha, L. R. P. Machado, E. M. Soares, D. R. Miquita, H. Miranda, C. Rabelo, O. P. V. Neto, A. Jori and L. G. Cançado , Carbon 161, 181 (2020). Crossref, ISI, Google Scholar
    • 29. V. V. Bon, S. I. Orysyk, V. I. Pekhnyo, V. V. Orysyk and S. V. Volkov , Polyhedron 26, 2935 (2007). Crossref, ISI, Google Scholar
    • 30. W. Shi, H. Fan, S. Ai and L. Zhu , New J. Chem. 39, 7054 (2015). Crossref, ISI, Google Scholar
    • 31. X. Wu, F. Tian, W. Wang, J. Chen, M. Wu and J. Zhao , J. Mater. Chem. C 1, 4676 (2013). Crossref, Google Scholar
    • 32. T. Fan, W. Zeng, W. Tang, C. Yuan, S. Tong, K. Cai, Y. Liu, W. Huang, Y. Min and A. J. Epstein , Nanoscale Res. Lett. 10, 55 (2015). Crossref, ISI, Google Scholar
    • 33. J. Canton and S. Grinstein , Measuring lysosomal pH by fluorescence microscopy, in Methods in Cell Biology, eds. F. PlattN. Platt, Chap. 5 (Academic Press, 2015), pp. 85. Google Scholar
    • 34. J. Zhang, M. Yang, W. Mazi, K. Adhikari, M. Fang, F. Xie, L. Valenzano, A. Tiwari, F. T. Luo and H. Liu , ACS Sens. 1, 158 (2016). Crossref, ISI, Google Scholar