Hemoperfusion in Poisoning, Kidney Failure, Liver Failure, and Immunology

The following sections are included:

• Introduction

  • Artificial kidney machine

  • Hemoperfusion based on artificial cells

• Development and Clinical Trials

  • Treatment of patients with severe accidental or suicidal poisoning

  • Hemoperfusion for removal of unwanted or toxic substances from blood under other conditions

  • Treatment of patients with terminal kidney failure

  • Treatment of patients with hepatic coma

  • Protein-coated artificial cells in immunoadsorption

• Basic Principle of Artificial Cell in Hemoperfusion

  • Permeability and transport characteristics

  • Experimental analysis

• Artificial Cells Containing Activated Charcoal in Hemoperfusion

  • Why use activated charcoal for artificial cell hemoperfusion?

  • Effects on embolism

  • Effects of hemoperfusion on platelets

  • Clearance of the ACAC artificial cell artificial kidney

  • Improvements in hydrodynamics

• Hemoperfusion in Acute Suicidal or Accidental Poisoning

  • Preclinical studies

  • First clinical trials in acute poisoning

  • Result of clinical trials on 11 adult patients with suicidal or accidental drug poisoning

  • Pediatric patient with accidental theophylline overdose

  • Routine clinical uses in patients around the world

• Hemoperfusion in Terminal Renal Failure Patients

• Hemoperfusion Alone Supplemented by Hemodialysis

  • General clinical results

  • First patient on long-term hemoperfusion

  • Hemoperfusion and removal of uremic metabolites

• Conjoint Hemoperfusion-Hemodialysis

• Miniaturized Artificial Kidney Based on Hemoperfusion-Ultrafiltration

• Hemoperfusion in Liver Failure

  • First observation of recovery of consciousness in hepatic coma

  • Results around the world on effect of hemoperfusion on hepatic coma

  • Control studies in galactosamine-induced hepatic failure rats

• Immunoadsorption

  • Protein coated artificial cells in immunoadsorption

• Detailed Procedures for the Laboratory Preparation of ACAC Hemoperfusion Device

  • The extracorporeal shunt chamber

  • Preparation of activated charcoal

  • Preparation of artificial cells containing activated charcoal

  • Procedure for hemoperfusion