Structural Proteomics in Relation to Signaling Pathways

The following sections are included:

• Introduction

• Nuclear Receptor Signaling Pathways

  • Nuclear Receptors and Structural Proteomic Data

  • Nuclear Receptor Signaling Pathways

• Specificity of Ligand Recognition

  • Discrimination of Cognate Ligand in Genomic Response

  • Alternative Pocket in the Vitamin D Receptor

• Signal Transduction in the NR Signaling Pathways

  • Structural Basis of the Transactivation Mechanism

  • Specificity of Comodulator Recruitment

• Histone Acetylase Complexes

  • Catalysis Mechanism of HATs

  • Docking the Hat Complex to Promoter or Gene Target

• Conclusion

• References