CHAPTER 4: IN VIVO BRAIN MICRODIALYSIS MEASUREMENTS IN HUMAN SUBJECTS DURING COGNITIVE TASKS

The following sections are included:

• Introduction

• Microdialysis: Basic principles and research in humans

• Study 1: Brain chemistry measurements during tasks using microdialysis catheters in awake patients with Parkinson’s disease

  • Experimental design and methods

    • Patient/subject characteristics

    • Recruitment and consent of subjects

    • Targets

    • Overview of the study procedures

    • Intra-operative experimental protocols

    • Placement of the microdialysis catheters into the STN or GPi

    • The non-declarative and declarative memory tasks

    • Overview of the conventional neurosurgical procedure for the placement of a deep brain stimulator

  • Risks to subject

  • Special precautions

  • Results

    • STN study

    • GPi study

• Study 2: Microdialysis measurements from the amygdala and hippocampus during tasks

  • Experimental design and methods

    • Patient selection and preoperative work-up

    • Cognitive testing

    • Tasks

    • The collection of microdialysate

  • Results

• Limitations

• Future directions

• References