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Volume 1 of this series focused mainly on small molecules which are intrinsically electroactive. Volume 2 continues to provide current approaches to real time measurements of essential species in the central nervous system. It describes microdialysis, a sampling technique, which facilitates the removal of small volumes of solution containing the analyte(s) of interest which can be subsequently separated by chromatography and analyzed by a range of techniques. These include electrochemistry, UV-Vis spectroscopy, fluorescence and mass spectroscopy. This approach affords the opportunity to measure a range of targets in real-time thus providing access to pharmacokinetic/pharmacodynamics measurements affording the possibility of measuring the disappearance of a drug after administration and the subsequent appearance of metabolites. Microdialysis further affords the ability to sample peptides and proteins of neurobiological interest.
Consistent with the goals of Volume 1, Volume 2 seeks to provide for scientists in the field of neurobiology a base of bioanalytical techniques that may not be familiar to them. Specific examples are provided and the fundamental basis of the technique is also covered.
Sample Chapter(s)
Chapter 1: Separation-Based Methods Combined with Microdialysis Sampling for Monitoring Neurotransmitters and Drug Delivery to the Brain (5,126 KB)
Contents:
- Separation-Based Methods Combined with Microdialysis Sampling for Monitoring Neurotransmitters and Drug Delivery to the Brain (Rachel A Saylor, Sara R Thomas and Susan M Lunte)
- Microdialysis for Pharmacokinetic and Pharmacodynamic Studies with Focus on the CNS (Margareta Hammarlund-Udenaes)
- Real-Time Neurochemical Monitoring Using Microdialysis (Michelle L Rogers and Martyn G Boutelle)
- In Vivo Brain Microdialysis in Human Subjects During Cognitive Tests (Robert J Buchanan, Conor M Gerace and Klevest Gjini)
- Advanced Microdialysis Approaches Resolve Differences in Serotonin Homeostasis and Signaling (Maureen M Sampson, Hongyan Yang and Anne M Andrews)
- Improving Temporal Resolution in Online Microdialysis/Liquid Chromatography (Jing Zhang, Khanh T Ngo, Stephen R Groskreutz and Stephen G Weber)
- Liquid Chromatography-Mass Spectrometry Analysis of Dialysate and Applications with Selective Neuronal Stimulation (Jenny-Marie T Wong, Samuel S Pappas and Robert T Kennedy)
- Derivatization Chemistries for Improved Detection of Monoamine Neurotransmitters and Their Metabolites in Microdialysis Samples by Liquid Chromatography with Fluorescence Detection and Tandem Mass Spectrometry (Jan Kehr and Takashi Yoshitake)
- Microdialysis Contributions to the Understanding of Reward and Addiction (Roy A Wise and Zhi-Bing You)
- Voltammetry Reveals How Mesolimbic Dopamine Relates to Instrumental Reward Seeking (Kate M Wassum)
- In Vivo Neurochemical Monitoring of the Crab Cancer Borealis via Microdialysis and Mass Spctrometry (Zhidan Liang and Lingiun Li)
- In Vivo Microdialysis Coupled with Selective Online Electrochemical Systems to Study Ascorbate Dynamics in the Rat Brain (Meining Zhang, Fei Wu and Langqun Mao)
- Open Volume Microfluidic Probes (Gavin D M Jeffries, Anna A Kim, Kiryl Kustanovich and Aldo Jesorka)
- Push–Pull Perfusion Sampling of Thin Neuronal Tissues (Scott A Shippy and Geovannie Ojeda-Torres)
- Microdialysis Flux Considerations (Julie A Stenken and Samuel L Patton)
- Advancing Intracranial Microdialysis Sampling and Measurements (Andrea Jaquins-Gerstl, Erika L Varner, Kathryn M Nesbitt and Adrian C Michael)
Readership: Students and researchers in biochemistry, neurobiology, neuroanatomy, biomedical sciences and bioengineering.
