Chapter 7: Cortical Sensitization and Reorganization
The following sections are included:
News and Views
Summary
Introduction
Cortical reorganization
LTP in the ACC after injury
Experimentally induced LTP and LTD
Presynaptic glutamate release
Postsynaptic AMPA receptor changes
Postsynaptic NMDA receptors
Calcium-stimulated AC1
Upregulation of AC1 in chronic visceral pain
Upregulation of PKMζ
Altered intrinsic properties after injury
Activation by allodynic stimulation
Loss of inhibition
Possible roles of microglia
Enhancement of ACC top-down facilitation
Conclusions
References