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EVALUATION OF THE UPTAKE OF CDDP-CONTAINING POLYMERIC MICELLES IN SINGLE PANCREATIC CANCER CELLS

Department of Nuclear Engineering and Management, School of Engineering, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan

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M. UESAKA

Department of Nuclear Engineering and Management, School of Engineering, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan

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S. MATSUYAMA

Department of Quantum Science and Energy Engineering, Tohoku University, Aramaki-Aza-Aoba 6-6-01-2, Aoba-ku, Sendai 980-8579, Japan

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Y. ITO

Department of Quantum Science and Energy Engineering, Tohoku University, Aramaki-Aza-Aoba 6-6-01-2, Aoba-ku, Sendai 980-8579, Japan

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K. ISHII

Department of Quantum Science and Energy Engineering, Tohoku University, Aramaki-Aza-Aoba 6-6-01-2, Aoba-ku, Sendai 980-8579, Japan

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, and

H. YAMAZAKI

Cyclotron and Radioisotope Center, Tohoku University, Aramaki-Aza-Aoba 6-3, Aoba-Ku, Sendai 980-8578, Japan

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https://doi.org/10.1142/S012908351000194XCited by:2 (Source: Crossref)

Abstract

Highly functionalized drugs delivered via a drug delivery system are expected to have less side effects and higher accumulation rates compared to conventional anticancer drugs. An understanding of the kinetics of drugs contained within a delivery system is necessary to obtain the maximum therapeutic effect. We performed micro-elemental analysis of human pancreatic cancer cells treated with cis-diamminedichloroplatinum(II) (CDDP)-containing polymeric micelles. The results showed that the platinum signals were distributed inside the cellular nuclei and the cytoplasm indicating that CDDP was delivered into the cells. The results from this study will be useful for designing an optimum carrier for platinum-containing anticancer drugs.

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