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Electrochemical Synthesis of Nickel–Copper Alloy Nanocomposite to Fabricate an Electrochemical Sensor for Uric Acid

Chunmei Zheng

School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, P. R. China

These authors contributed equally to this work.

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Fubin Pei

School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, P. R. China

These authors contributed equally to this work.

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Shasha Feng

School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, P. R. China

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Yi Wu

School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, P. R. China

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Yong Ding

School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, P. R. China

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, and

Wu Lei

https://orcid.org/0000-0003-2242-7067

School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, P. R. China

E-mail Address: leiwuhao@njust.edu.cn

Corresponding author.

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https://doi.org/10.1142/S1793292020501532Cited by:2 (Source: Crossref)

Abstract

In this work, a sensor for quantitative detection of uric acid (UA) is successfully prepared by electrodepositing Nickel–Copper (Ni–Cu) alloy nanoparticles on poly (3,4-ethyldioxythiophene) modified nitrogen-containing grapheme (Ni–Cu/PEDOT/NGE). The anchoring of PEDOT and Cu–Ni alloy nanoparticles on NGE not only prevents the agglomeration of NGE, but also improves the catalytic activity of the composites. Ni–Cu/PEDOT/NGE shows high electrochemical performance to UA and the oxidation of UA on its interface was an action with two protons and two electrons. Under the optimized condition, the response current of the sensor is linear with UA concentration within the range of 0.1–10 $μ$ M and 10–50 $μ$ M. A low detection limit of 0.059 $μ$ M at S/ $N = 3$ is obtained. Additionally, the fabricated electrochemical sensor with good sensitivity and selectivity to UA may be promising for practical clinical testing.

Keywords:

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