We prove that many four-strand pretzel knots of the form K=P(2n,m,−2n±1,−m) are not topologically slice, even though their positive mutants P(2n,−2n±1,m,−m) are ribbon. We use the sliceness obstruction of Kirk and Livingston [Twisted Alexander invariants, Reidemeister torsion, and Casson–Gordon invariants, Topology38 (1999) 635–661], related to the twisted Alexander polynomials associated to prime power cyclic covers of knots.