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Effects of different ratios of Ni to Al on the ductility and toughness of Ni33+xAl28-xCr30Mo4Nb5 (x=0, 6, 9, 12) alloys are investigated. High temperature compression test is also conducted. The results show that with ratio of Ni to Al up to 1.77, γ phase precipitation result in ductility and fracture toughness enhanced at room temperature. The reinforced Cr2Nb-type phase and γ phase benefit for the high temperature strength and room temperature ductility, respectively.