In this paper, we investigate the cyclicity of the 2-class group of the first Hilbert 2-class field of some quadratic number field whose discriminant is not a sum of two squares. For this, let p1≡p2≡−q≡1(mod4) be different prime integers. Put 𝕜=ℚ(√p1p2q), and denote by C𝕜,2 its 2-class group and by 𝕜(1)2 (respectively 𝕜(2)2) its first (respectively second) Hilbert 2-class field. Then, we are interested in studying the metacyclicity of G=Gal(𝕜(2)2/𝕜) and the cyclicity of Gal(𝕜(2)2/𝕜(1)2) whenever the 4-rank of C𝕜,2 is 1.