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This article reviews some results of a policy research project addressing agro-food SME trade promotion in Southeast Asian and Western African developing economies. The project was conducted by a group of scientific institutions based in Hanoi (Vietnam), Ouagadougou (Burkina Faso) and Geneva (Switzerland). The article documents the capacity of Southeast Asian and Western African agro-food SMEs to access domestic, regional and possibly global markets, as well as the role of international cooperation (public and private) to promote agro-food SME trade within and outside Southeast Asia, and Western Africa respectively. The article also calls for interested OECD and non-OECD partners to contribute to two types of South-South trade emerging innovations in the field of SME agro-business matching, namely, the promotion of existing and new business linkages between Southeast Asian and Western African agro-food SMEs (trade, finance and appropriate technology transfer), and the promotion of public-private partnerships to facilitate such agro-food SME business linkages between far distant Southeast Asia and Western Africa.