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Simulations Plus Announces Preliminary Success in Malaria Drug Design Project.

xCELLigence System Evaluated in EU Project to Replace Animal Experiments in Cosmetics Industry.

Progress in $100 Million Biodiesel and Commercial Fish Food Project.

QIAGEN and Bio-X Center Open Shanghai Translational Medicine Lab.

Index Ventures Launches First 150m Life Sciences Fund.

Enzo Biochem Expands Distribution with Japan's Cosmo Bio.

Maxwell Biotech Venture Fund Invests in Hepatitis B/D.

ScinoPharm and NHRI Announce Jointly Developed Diabetes Drug.

Calibr: A New Paradigm for Academic – Industry Cooperation.

Biocon and Pfizer End Commercialization Agreement.

Plandai Biotech Demonstrates Significance of Flavonoid & Polyphenol Bioavailability.

Ceva Uses ProBioGen's AGE1.CR Cell Line for Viral Vaccine Production.

Quintiles to Sign Memorandum of Agreement with Malaysia Biotechnology Corporation.

Fluidigm China opens its doors.

Brazil Center for Excellence in Bioinformatics at FIOCRUZ chooses Convey to advance genomics.

American CryoStem and Protein Genomics to jointly develop stem cell applications for wound healing.

BASF and Catalent join forces to solve bioavailability challenges.

AB SCIEX and Phenomenex develop food safety solution for India.

This paper reveals the biomechanical properties and hemodynamics performance of the convertible vena cava filter while it was in the process of implantation and conversion in the blood vessels. This paper uses the finite element method and computational fluid dynamics to analyze the interaction mechanism and influence of the convertible vena cava filter while the filter was in the process of implantation and conversion in the blood vessels. Additionally, six pigs were used as experimental samples to verify the effects of the filter in the blood vessels. The computer-aided simulation results showed that it was easier to cause damage to the vessel wall prior to the filter being converted into support. On the contrary, the stress, the peak value of the blood vessel’s stress, the outlet velocity, and the supporting stiffness were reduced after the conversion. Due to the intimal hyperplasia, the supporting element was easy to fix on the inner surface of the blood vessels, which was helpful for the correct positioning of the filter after the conversion. Meanwhile, the animal experiments proved that the surface of inferior vena cava wall was relatively smooth, and the filter did not cause vascular wall rupture. The computer-aided simulation and animal experiments proved the reasonability of the structure of the filter design, and that the filter has good biomechanical properties. The results will provide more scientific reference for the clinical treatment and design of the filter.

The objective of this study was to establish an ovine model for CH-VAD (CH Biomedical Inc., JiangSu, China) implantable ventricular assist device (IVAD) to evaluate experimental protocols, including anesthesia management, surgical process, autopsy criteria and a validated anticoagulation procedure. Method: IVAD was implanted into the chest of sheep without stopping the beating heart through a left thoracotomy, and the inflow cannula was connected to the left ventricular apex and the outflow cannula was anastomosed to the descending aorta. Results: Totally 23 cases were established: 6 died of an anaesthetic or surgical reasons, one died of lung infection, the other 16 cases survived for more than 15 days, among which four cases were terminated because of decrease of pump flow and the other 12 cases survived for more than 30 days. Conclusions: Sheep models suitable for implantation of CH-VAD implantable LVAD were successfully established and the appropriate safety evaluation indicators of this model were validated in the course of the animal experiments, and the survival rate of the experiments were improved gradually over time.

Objective: Animal experiments and clinical trials were carried out to evaluate the efficiency of a new stent for the treatment of iliac vein stenosis. Methods: The new iliac vein stent and the control stent were implanted, respectively, into the 12 experimental pigs. Digital Subtraction Angiography was done separately at the same day, 14th, 30th, 60th and 90th day after stent implantation to observe the stent deployment. One patient was implanted with a new iliac vein stent. Digital subtraction angiography (DSA) was done after the operation to calculate the lumen loss value and lumen loss rate of the stent and evaluate the performance of the new iliac vein stent at 12 months of follow-up. Results: The mechanical experiment and finite element analysis of the stent proved that the radial support force of the new stent is significantly better than that of the control stent. In animal experimental verification, both groups of stent were released satisfactorily during implantation. No obvious stent displacement was found at each time point. The patency rate of stents was 100%. Except for a small amount of old thrombosis in the stent in the control group, no other stents were found in that condition. The diameter of the stent lumen was retracted in different degrees in both groups after the operation, but no significant statistical difference was found in the comparison of the stent lumen loss rate at each relative inspection day. Conclusion: The new nickel-titanium alloy iliac vein stent has excellent radial support performance, which may be an ideal iliac vein stent.