Narrow Results

Acquired immunodeficiency syndrome (AIDS) caused by human immunodeficiency virus (HIV) infection is a serious public problem threatening global health. At present, although “cocktail therapy” has achieved significant clinical effects, HIV still cannot be completely eradicated. Furthermore, long-term antiviral treatment has caused problems such as toxic side effects, the emergence of drug-resistant viruses, and poor patient compliance. Therefore, it is highly necessary to continue to search for high-efficient, low-toxic anti-HIV drugs with new mechanisms. Natural products have the merits of diverse scaffolds, biological activities, and low toxicity that are deemed the important sources of drug discovery. Thus, finding lead compounds from natural products followed by structure optimization has become one of the important ways of modern drug discovery. Nowadays, many natural products have been found, such as berberine, gnidimacrin, betulone, and kuwanon-L, which exert effective anti-HIV activity through immune regulation, inhibition of related functional enzymes in HIV replication, and anti-oxidation. This paper reviewed these natural products, their related chemical structure optimization, and their anti-HIV mechanisms.

Australian Scientists in Real-time Virtual Surgery.

China Invests US$36 Million to Set up Plant Gene Banks.

India, Germany to Jointly Promote Biotech Research.

Firms Urged to Lower Costs of Anti-HIV Drugs.

Japanese Private Sector May Stop Funds to AIDS Body.

Malaysian Institute Collaborates with Drug Firm.

Parkinson’s Disease Research Gets NZ$1.2 Million Funding.

Online Food Composition Database Available.

NZ Recalls Blood Pressure Medicine.

Conference on Biotechnology Awareness in the Philippines.

Singapore Sets up New Cancer Research Body.

Singapore Attracts Attention of Life Sciences Firms.

Thailand Ponders Adopting GM Crops.