In this study, we have prepared PLGA (poly(D,L-lactic-co-glycolic) acid) nanospheres (NPs) loaded with magnetic fluid (MFPEG) as a magnetic carrier and anticancer drug Taxol by the nanoprecipitation method. The PLGA was utilized as a capsulation material due to its biodegradability and biocompatibility. Taxol – an important anticancer drug was chosen for its significant role against a wide range of tumours. The morphology and particle size distributions of the prepared NPs were investigated using scanning electron microscope (SEM) and PCCS technique. The results confirmed the spherical shape of the prepared NPs with size ~ 200 – 250 nm in diameter. The differential scanning calorimetry (DSC) and infrared spectroscopy (FTIR) measurements confirmed the incorporation of Taxol into the magnetic PLGA NPs. Then the effect of ionic strength on the colloidal stability of PLGA, magnetite, Taxol, and composite nanospheres are shown. Finally, the results of toxicity of prepared samples are presented.
