In this paper, we calculate the Kauffman polynomials F(K(p,q);a,z)F(K(p,q);a,z) of Kanenobu knots K(p,q)K(p,q) with p,qp,q half twists and determine their spans on the variable aa completely. As an application, we determine the arc index of infinitely many Kanenobu knots. In particular, we give sharper lower bounds of the arc index of K(2n,−2n)K(2n,−2n) by using canonical cabling algorithm and the 2-cable ΓΓ-polynomials. Moreover, we give sharper upper bounds of the arc index of some Kanenobu knots by using their braid presentations.