In this paper, we classify connected arc-transitive graphs of valency 11 and of order 4n, where n is an odd square-free integer. In particular, there are four infinite families of such graphs, which have a minimal arc-transitive automorphism group isomorphic to PSL(2,r), PGL(2,r), Z2×PSL(2,r) and PSL(2,r)×Z11 separately, where r≡±1(mod11) is a prime. Moreover, examples for each class are constructed.