We study the distribution of the generalized gcd and lcm functions on average. The generalized gcd function, denoted by (m,n)b, is the greatest bth power divisor common to m and n. Likewise, the generalized lcm function, denoted by [m,n]b, is the smallest bth power multiple common to m and n. We derive asymptotic formulas for the average order of the arithmetic, geometric, and harmonic means of (m,n)b. Additionally, we also deduce asymptotic formulas with error terms for the means of (n1,n2,…,nk)b, and [n1,n2,…,nk]b over a set of lattice points, thereby generalizing some of the previous work on gcd and lcm-sum estimates.