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Let R be a prime ring of characteristic different from 2, Q be its maximal right ring of quotients, and C be its extended centroid. Suppose that f(x1,…,xn) is a non-central multilinear polynomial over C, 0 ≠ p ∈ R, and F, G are two b-generalized derivations of R. In this paper we describe all possible forms of F and G in the case pG(F(f(r))f(r))=0 for all r=(r1,…,rn) in Rn.