In this paper, we study multivariate Gabor frames in matrix-valued signal spaces over locally compact abelian (LCA) groups, where the lower frame condition depends on a bounded linear operator Θ on the underlying matrix-valued signal space. This type of Gabor frame is also known as a multivariate Θ-Gabor frame. By extending work of Gˇavruta, we present necessary and sufficient conditions for the existence of Θ-Gabor frames of multivariate matrix-valued Gabor systems. Some operators which can transform multivariate matrix-valued Gabor and Θ-Gabor frames into Θ-Gabor frames in terms of adjointable operators are discussed. Finally, we give a Paley–Wiener-type perturbation result for multivariate matrix-valued Θ-Gabor frames.