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In this paper we extend the framework of reaction systems by introducing (extended) zoom structures which formalize a depository of knowledge of a discipline of science. The integrating structure of such a depository (which is a well-founded partial order) allows one to deal with the hierarchical nature of biology. This leads to the notion of an exploration system which consists of (1) a static part which is a depository of knowledge given by an extended zoom structure , and (2) a dynamic part given by a family of reaction systems . In this setup the depository of knowledge is explored by computations/processes provided by reaction systems from , where this exploration can use/integrate knowledge present on different levels (e.g., atomic, cellular, organism, species, … levels).