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  • articleNo Access

    CELL/SYMBOL COMPLEXITY OF TISSUE P SYSTEMS WITH SYMPORT/ANTIPORT RULES

    We consider tissue P systems with symport/antiport rules and investigate their computational power when using only a (very) small number of symbols and cells. Even when using only one symbol, we need at most six (seven when allowing only one channel between a cell and the environment) cells to generate any recursively enumerable set of natural numbers. On the other hand, with only one cell we can only generate regular sets when using one channel with the environment, whereas one cell with two channels between the cell and the environment obtains computational completeness with five symbols. Between these extreme cases of one symbol and one cell, respectively, there seems to be a trade-off between the number of cells and the number of symbols. For example, for the case of tissue P systems with two channels between a cell and the environment we show that computational completeness can be obtained with two cells and three symbols as well as with three cells and two symbols, respectively. Moreover, we also show that some variants of tissue P systems characterize the families of finite or regular sets of natural numbers.

  • articleNo Access

    Understanding dynamic changes in live cell adhesion with neutron reflectometry

    Neutron reflectometry (NR) was used to examine various live cells' adhesion to quartz substrates under different environmental conditions, including flow stress. To the best of our knowledge, these measurements represent the first successful visualization and quantization of the interface between live cells and a substrate with sub-nanometer resolution.

    In our first experiments, we examined live mouse fibroblast cells as opposed to past experiments using supported lipids, proteins, or peptide layers with no associated cells. We continued the NR studies of cell adhesion by investigating endothelial monolayers and glioblastoma cells under dynamic flow conditions. We demonstrated that neutron reflectometry is a powerful tool to study the strength of cellular layer adhesion in living tissues, which is a key factor in understanding the physiology of cell interactions and conditions leading to abnormal or disease circumstances. Continuative measurements, such as investigating changes in tumor cell — surface contact of various glioblastomas, could impact advancements in tumor treatments. In principle, this can help us to identify changes that correlate with tumor invasiveness. Pursuit of these studies can have significant medical impact on the understanding of complex biological problems and their effective treatment, e.g. for the development of targeted anti-invasive therapies.

  • articleNo Access

    General News

      New Biotech Research Lab to Open in Malaysia.

      AstraZeneca Considers Move to Asia.

      Scientists Discover how the Ebola Virus Infects Cells.

    • articleNo Access

      Bioboard

        AUSTRALIA – New Stem Cell Center Gives Hope for Stroke Damage.

        AUSTRALIA – Sun Beds Killing 43 Aussies A Year.

        CHINA – Chinese Skin Cream Recalled After Steroid Found.

        CHINA – UN Urges China to Revamp Food Safety after Milk Crisis.

        CHINA – Key Proteins Identified In the Quest for Male Contraceptive.

        CHINA – Gene that May Contribute to Improved Rice Yield Identified.

        CHINA – A New Institution to be Formed by Teaming up Biological Institutes in Beijing.

        CHINA – Big Pharma Ranks China as No. 1 Destination in Asia for Pharmaceutical Outsourcing.

        INDIA – Reliance Life Sciences Launches India's First Portal for Breast Cancer Genomics.

        INDIA – New Health Scheme Launched in Kerala.

        INDIA – Nobel Biocare Introduces New Dental Implant Program in India.

        INDIA – Malaria Drug through Synthetic Biology.

        JAPAN – Sleep Disorder Due to Genetic Mutation.

        NEW ZEALAND – Crop and Food and Hortresearch to Merge.

        SINGAPORE – NUS Researchers Create Antibody that may Eradicate Viral Diseases.

        SINGAPORE – AMO Opens Eye-Care Training Center in Singapore.

        SINGAPORE – Singapore and New Zealand Set Up First Joint R&D Research Fund in Heart Disease and Cancer.

        SINGAPORE – More Singaporeans Expected to Seek Help for Clinical Depression, Anxiety.

        SINGAPORE – Moleac Launches Presence in Europe.

        SINGAPORE – New Study Shows Heterogeneity in Brain Tumor Cells-of-Origin.

        SINGAPORE – Singapore Launches New Cancer Research Centre of Excellence (CRCE) to Study Asian Cancers.

        SINGAPORE – Scientists Identify Gene that May Make Humans More Vulnerable to Pulmonary Tuberculosis.

        SINGAPORE – BioServe Introduces Customizable DNA Panels for Genetic Research.

        TAIWAN – Unitech Launches Its Healthcare PDA to Catch Medical Market Trend.

        TAIWAN – Controversies Around the Set-up of Heavy-Ion Therapy Facility in Taiwan.

        TAIWAN – Researchers Find Method to Extract DHA from Algae.

      • articleNo Access

        Research and Findings

          Bioremediation to Keep Atrazine from Waterways.

          Fifth Brain Disorder Gene Located.

          Moving towards Emerging Field of Mechanobiology.

          Singapore and Israel Join Forces in Research and Innovation.

        • articleNo Access

          Feature

            Osteopontin: In and Out in Immunity.

            The Emerging Potential of Immunoinformatics Prediction Tools.

          • articleNo Access

            Bioboard

              AUSTRALIA – World-Class Cancer Center to be Built in Parkville.

              AUSTRALIA – Cure Found for Devastating Muscle Disease.

              AUSTRALIA – HIV Test to Help Monitor Sufferers.

              AUSTRALIA – Radium Weed Weeds Out Sun Spots, Skin Cancer.

              AUSTRALIA – Kava Safe and Effective in Reducing Anxiety.

              CHINA – CAS Develops New Salt-tolerant Wheat.

              CHINA – Search for Passengers on Flights with Flu Case.

              HONG KONG – Hong Kong Confirms Asia's 1st Swine Flu Case.

              INDIA – Indian Healthcare Market to Grow Despite Slowdown.

              INDIA – WHO Lifts Vaccine Embargo on India.

              JAPAN – Scientists Create World's First Transgenic Monkeys.

              JAPAN – Japan Swine Flu Cases Surge.

              NEW ZEALAND – New Frontiers in Gene Behavior.

              NEW ZEALAND – Innovative Pet Food Research Consortium Launched.

              SINGAPORE – 50 Receive Healthcare Humanity Awards.

              SINGAPORE – No-Go for Swine Flu Parties.

              SINGAPORE – Asia's First Combined Heart and Liver Transplant.

              SINGAPORE – Singapore to Host Conference on Tobacco or Health.

              SINGAPORE – Diabetes Hits Asia's Youth.

              SOUTH KOREA – $14.6 mn for Fight Against New Flu.

              TAIWAN – Flu Vaccine to be Available by End of Year.

              TAIWAN – Mutation in Gene allows Cancer to Spread.

              TAIWAN – Scientists Find Ways to Improve Cancer Drugs.

              TAIWAN – Team Makes Discovery in Search for New Antibiotic.

              TAIWAN – Taiwan Tags Sixteen Countries with Yellow Travel Alert Over Flu.

              TAIWAN – Team Makes Breakthrough in Therapy for Childhood Cancer.

              THAILAND – Thailand Tries to Become Starch-Production Hub.

              THAILAND – Thailand and Taiwan to Begin Biotech Cooperation Plan.

              VIETNAM – US gives Vietnam Protective Bird Flu Equipment.

              OTHER REGIONS — UNITED STATES – Over 52's May Be Better Protected.

            • articleNo Access

              Industry Watch

                Benitec MOU with Biomics Biotechnologies China.

                Arkema & Aussie Chemeq Sign Manufacturing Cooperation Agreement.

                AstraZeneca and Mental Health Research Institute in Australia Announce Collaboration to Improve Early Detection of Alzheimer's Disease.

                Avexa Gets CSIRO Investment.

                Living Cell Technologies' Encapsulated Choroid Plexus Cells May Be Used To Treat Hearing Loss.

                Sundia MediTech Acquires Protein Folding Technology.

                Beijing Cancer Hospital Introduces Fast and Precise RapidArc Radiotherapy Cancer Treatments.

                Zydus Cadila and Karo Bio's Research Collaboration has Generated Promising Lead Compounds.

                ICON Acquires Veeda Laboratories Limited.

                Novavax-Cadila to Conduct Swine Flu Clinical Trials.

                Axygen & Astellas form JV to Develop Protein Drugs.

                Rexahn, KRICT to Develop Anti-Cancer Drugs.

                Japan's Largest Pharmaceutical Firm Opens Regional HQ in Singapore.

              • articleNo Access

                Research News

                  Dow AgroSciences, NemGenix Establish New Collaboration in Plant Biotechnology Research.

                  A*STAR Scientists Discover 'FAIM' Function.

                  Thailand Develops Seed Viruses for H1N1 Vaccine Production.

                • articleNo Access

                  Bioboard

                    AUSTRALIA – "Worm" Treatment for Auto-Immune Disorders.

                    AUSTRALIA – New Imaging Agent for Early Diagnosis of Skin Cancer.

                    AUSTRALIA – "ECG for The Mind" Fast-Tracks Depression Diagnosis in 60 minutes.

                    AUSTRALIA – Seven Aussie Researchers Awarded Gates Foundation Grants.

                    CHINA – Tougher Flu Control Work in Western Regions of China.

                    INDIA – Drought-Tolerant Crops that can Respond to Climatic Stress.

                    KOREA – Korea Raised Flu Alert for Preparedness.

                    SINGAPORE – Southeast Asia's First Kilo Laboratory Opens in Singapore.

                    SINGAPORE – Endow Robots with Fake Skin for that "Human Touch".

                    SINGAPORE – World's First Semi-Cloned Fish.

                    SINGAPORE – A Novel Fly Model of Parkinson's Disease Developed by Singapore Researchers.

                    SINGAPORE – Singapore Scientists Play Key Role in Genome 10K Project.

                    SINGAPORE – Findings Show H1N1 Virus No Different from Seasonal Flu.

                    TAIWAN – Umbilical Cord Blood Transplant Effective in Stroke Treatment.

                    TAIWAN – Adequate Folic Acid Intake Reduces Cancer Risk.

                    TAIWAN – Taiwan Scientists Find Key to Immune Response.

                    TAIWAN – Rice's Flood-tolerant Properties of Rice Explained.

                    TAIWAN – Early Detection by Nanotechnology Eases Osteoarthritis Treatment Costs.

                    EUROPE – Breakthrough Boosts Hope for Breast Cancer Treatment.

                    EUROPE – The Missing Chromosome 8 Can Suppress Cancers.

                    NORTH AMERICA – Access to Medical Care to Breast Cancer in Developing and Poor Nations.

                    NORTH AMERICA – H1N1 Confirmed in Cat in Iowa.

                    NORTH AMERICA – HIV-1 Genome Revealed.

                    NORTH AMERICA – The Internet Way to Take Control of Your Health.

                    NORTH AMERICA – Mold in Stale Grains Causes Cancer.

                  • articleNo Access

                    People Watch

                      A*STAR Scientist Receives International Award for Innovation in Healthcare Technology.

                      Six Clinician Scientists Receive Funding Support for Translational and Clinical Research.

                      Japanese Stem Cell Scientist Wins Kyoto Prize.

                      BIOTEC Researcher Wins Great Gigabase Grant.

                    • articleNo Access

                      Feature

                        Neem: A Wonder Tree.

                        Bacteria Living on Arsenic Discovered.

                        Temsirolimus Approved in Singapore for Advanced Renal Cell Carcinoma.

                        Attune™ Acoustic Focusing Cytometer.

                        Securing Genetic Diversity of Rice in 'Doomsday Vault'.

                        Leica Opens New Dimension in Spectral Imaging.

                      • articleNo Access

                        Research and Findings

                          The Benefits of Perforin Revealed.

                          Singapore Scientists First to Perform the Largest Genome-wide Association Study on Central Corneal Thickness.

                          Molecular Simulations Confirm Role of Functional Rotation in Multidrug Resistance.

                        • articleNo Access

                          BIOBOARD

                            AUSTRALIA – Four Anti-cancer Compounds Discovered.

                            AUSTRALIA – New Cell Type Boosts Immunity to Infection.

                            AUSTRALIA – Brain Malfunction Could Cause Restless Legs.

                            AUSTRALIA – New Treatment to Heal Spinal Injuries.

                            AUSTRALIA – Possible Breakthrough in Parkinson's.

                            CHINA – Chinese Medicine Could Double Chances of Conceiving Child.

                            CHINA – China to Build ADR Monitoring System.

                            CHINA – Brown Rice Could Make Blood Protein.

                            CHINA – Chinese Herbal Cures Linked to Cancer.

                            CHINA – Chinese Researchers Tap GPU Supercomputer for World's First Simulation of Complete H1N1 Virus.

                            CHINA – Chinese Scientists Discover Key Protein to More Efficiently Produce Stem Cells.

                            CHINA – Chinese Scientists Identify Novel Schizophrenia Susceptibility Gene.

                            INDIA – AIIMS Director Calls for Strengthening Rural Healthcare.

                            KOREA – Hair Growth Research with Nanoemulsions Receives Award in Korea.

                            SINGAPORE – New Pill for Advanced Lung Cancer Patients.

                            SINGAPORE – Breakthrough by IBN and IBM Named Top 10 World Changing Ideas by Scientific American.

                            SINGAPORE – EpiGen Announces Collaboration with Nestlé.

                            THAILAND – Using Fluidized Bed Reactor for Phenolic Wasterwater Treatment.

                            OTHER REGIONS — First Artificial Windpipe Graft a Success.

                            OTHER REGIONS — Stem Cells Fix Broken Heart.

                          • articleNo Access

                            EYE ON CHINA

                              Biotechnology unveils secrets of Chinese medicine.

                              Climate change a mixed blessing for wheat, say experts.

                              NTOU identified germ cells and somatic cells in coral bodies for the first time in the world.

                              Researchers tabulate disturbing changes and disappearance in biodiversity in Southern Taiwan coral reefs over last 26 years.

                              NCKU research team discovers new complex in treating cancer.

                              Chinese scientists successfully crack the genome of diploid cotton.

                              Taiwan's healthcare market boosted by aging population.

                              Researchers develop mouse model of common motor neuron disease pinpointing TDP-43 protein as likely cause.

                            • articleNo Access

                              BIOBOARD

                                INDIA – Bioven starts BV-NSCLC-001 Phase III trial in NSCLC.

                                INDIA – Initiative in Chemical Biology and Therapeutics.

                                PHILLIPPINES – Asia–Pacific Analysis: The slow road to green energy.

                                SINGAPORE – Takeda progressing well in Asia with New Drug Applications.

                                SINGAPORE – NTU and University of Warwick boost brainpower in global neuroscience research.

                                THAILAND – Thai PhD. student awarded Monsanto's Beachell–Borlaug International Scholarship for rice improvement research.

                                EUROPE – Open access will change the world, if scientists want it to.

                                UNITED STATES & CANADA – Verisante places Aura Beta Units for safety, verification testing in B.C., Alberta and Ontario clinics.

                                UNITED STATES & CANADA – Life Technologies sets new worldwide standard for criminal forensic testing with introduction of GlobalFilerTM Express Kit.

                                UNITED STATES & CANADA – How immune cells can nudge nerves to regrow.

                                UNITED STATES & CANADA – Improved Genomic Target Selection Using IDT Oligos.

                                UNITED STATES & CANADA – US team uncover non-invasive method for diagnosing epilepsy.

                              • articleNo Access

                                FEATURES

                                  Metabolic Syndrome and Diabetes: Current Asian Perspectives.

                                  A Crisis in the Development of Antibiotics.

                                  The Marketing of Unapproved Stem Cell Products: An Industry-wide Challenge.

                                  Draining the Goodwill of Science – The Direct-to-Consumer Genetic Testing Industry in East Asia.

                                  Biodiesel – From Lab to Industry.

                                  The Appearance and Development of Commercial Laboratories in China.

                                  Cord Blood Banking – To Go Public or Stay Private.

                                  Open Source – The Future of Drug Discovery.

                                  VACCINES – Where are we headed?

                                  Leveraging on External Expertise.

                                • articleNo Access

                                  BIOBOARD

                                    INDIA – Lack of access to technology ‘hampers detection of substandard drugs’.

                                    JAPAN – Daiichi Sankyo announces development of nucleic acid treatment for Duchenne muscular dystrophy utilizing proprietary technology.

                                    SINGAPORE – IBN creates unlimited source of human kidney cells.

                                    SINGAPORE – Dyesol and Singapore's NTU sign agreement.

                                    THE PHILIPPINES – Global biotech/GM crop plantings increase 100-fold from 1996.

                                    AUSTRALIA – Phosphagenics further expands pain portfolio.

                                    AUSTRALIA – Primary Health Care signs Australia distribution agreement for iGeneScreen™ prenatal test.

                                    AUSTRALIA – Folic acid in pregnancy linked with reduced autism risk.

                                    AUSTRALIA – Phylogica and Bio-Link collaborate to commercialize anti-inflammatory Phylomers.

                                    AUSTRALIA – ABRAXANE® plus gemcitabine improves survival in Phase III study of patients with advanced pancreatic cancer.

                                    CANADA – Verisante Technology, Inc. announces first sales of aura, a revolutionary medical device for the detection of skin cancer.

                                    EUROPE – Project eyes robust medical technology for poor countries.

                                    UNITED KINGDOM – Asthma sufferers have more lung fungi.

                                    UNITED KINGDOM – Pioneering drug discovery gets major funding to move to next stage.

                                    UNITED STATES – Gilead's sofosbuvir for hepatitis C meets primary endpoint in fourth pivotal Phase III study.

                                    UNITED STATES – Eleven Biotherapeutics publishes data on EBI-005, a novel IL-1 inhibitor protein for topical treatment of dry eye disease.

                                    UNITED STATES – Phase I/II trial of ADXS-HPV in anal cancer conducted by Brown University Oncology Group.

                                    UNITED STATES – Scopolamine: An old drug with new psychiatric applications.

                                    UNITED STATES – New bioengineered ears look and act like the real thing.

                                    UNITED STATES – To trap a rainbow, slow down light.

                                    UNITED STATES – AB SCIEX responds to milk contamination concerns with new method to detect dicyandiamide.

                                  • articleNo Access

                                    BIOBOARD

                                      AUSTRALIA – HIV trial validates novel drug mechanism.

                                      SINGAPORE – IBN engineered artificial human livers for drug testing and discovery.

                                      SINGAPORE – Scientists at A*STAR's Genome Institute of Singapore catch evolving germs and cancer cells early.

                                      SINGAPORE – DocDoc and Chatter Buzz Media enter strategic partnership to launch Asia's first healthcare Content Marketing Network.

                                      UNITED STATES – New method developed to expand blood stem cells for bone marrow transplant.

                                      UNITED STATES – Fibrocell/UCLA study on human skin cells yields promising results.

                                      UNITED STATES – Metal stents are effective treatment for blocked bile ducts.

                                      UNITED STATES – Pain drug may prevent preemie lung damage.

                                      UNITED STATES – Gene x3 helps corn grow in acidic soil.

                                      UNITED STATES – Cancer Genetics selected by Gilead Sciences, Inc. to provide clinical trial services for chronic lymphocytic leukemia.

                                      UNITED KINGDOM – DaTSCAN™ SPECT imaging demonstrates impact on the diagnosis of patients with clinically uncertain dementia.

                                      AFRICA – Failing vaccine strategies need to be revamped.

                                      AFRICA – RegeneCure's membrane implant shows 40% accelerated healing time of severe bone fractures.

                                    • articleNo Access

                                      EYE ON CHINA

                                        Difference in rainfall between wet and dry seasons is increasing worldwide.

                                        Rare carbon molecule detected in dying star gives glimpse of stellar evolution.

                                        Whole genome sequencing of wild rice reveals the mechanisms underlying Oryza genome evolution.

                                        BGI and TGAC join efforts to tackle global challenges in food security, energy and health.

                                        A regeneration system for tartary buckwheat invented by CIB.

                                        A new approach for the reduction of carbon dioxide to methane and acetic acid.

                                        Launch of the Chinese-German Center for Bio-Inspired Materials at the Mainz University Medical Center.

                                        Science: The early bird loses an ovary.

                                        Disruptions of functional brain connectomes in individuals at risk for Alzheimer's disease.

                                        A breakthrough in carbohydrate-based vaccine: One vaccine targets three unique glycan epitopes on cancer cells and cancer stem cells.

                                        BSD Medical signs exclusive agreement for distribution of BSD's cancer treatment hyperthermia system in Taiwan.

                                        Catalent announces major China expansion with two new facilities.