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The grinding fluid dedicated for ceramics is one of the effective methods to realize efficient grinding of ceramics. The blockage of grinding fluid dedicated for ceramics is researched in this paper. On basis of the fundamental principles of organic chemistry, the influence from changes of organic acid, organic alcohol carbon chain and functional group on the blockage of grinding wheel are investigated respectively in this paper. According to the experiment result: the blockage area of grinding wheel increases along with the increase of low-carbon chain acid and alcohol, but for the long-carbon chain, the blockage area on grinding wheel decreases with the increase of the number of carbons; the influences of adding functional group are highly related to the hydrophile-lipophile (HLB value), which is finally formed by organic matters and has regular changes.