Ordered structures such as crystalline materials may help to enhance the nuclear interaction yield. Indeed, the aligned atoms act as a single entity on impinging charged particles, causing the trajectory to pass from its random motion to a deterministic one. In fact, Monte Carlo simulations suggested that specific crystal alignments allow for the enhancement of the production rate of nuclear inelastic reactions, because particles are forced to pass by the atomic nuclei more frequently than would happen in an amorphous material. Recent measurements we carried out at the AN2000 accelerator of the National Institute for Nuclear Physics Legnaro National Laboratories showed the experimental evidence of such an effect. A 643.5 keV collimated proton beam was used to induce the 18O(p,α)15N reaction in an Al2O3 substrate oriented along the <0001> axis. The capability of manipulating such an effect paves the way to studying innovative targets for the enhancement of the nuclear interaction yield with a constant density.