Narrow Results

INDIA – A novel form of gene regulation in bacteria.

INDIA – Algal biofuels are no energy panacea.

JAPAN – Medical Data Vision enhances the quality of medical care with Actian Vectorwise.

SINGAPORE – Singapore heart surgeon to receive honour from The Royal College of Surgeons of Edinburgh.

SINGAPORE – ELGA^® to deliver innovative water purification at new Singapore General Hospital expansion.

AUSTRALIA – Specialised Therapeutics Australia: New drug to fight hospital superbug infection.

AUSTRALIA – Group of genes hold the clue in migraine cases.

AUSTRALIA – CT scans can triple risk of brain cancer, leukemia.

BRAZIL – Science can do more for sustainable development.

MIDDLE EAST – Particles and persecution: why we should care about Iranian physicists.

EUROPE – Medicyte coordinates EU-funded collaboration on Biomimetic Bioartificial Liver.

EUROPE – Selvita and Orion Pharma achieve a research milestone in Alzheimer's Disease Program.

EUROPE – Zinforo (ceftaroline fosamil) receives positive CHMP opinion in the European Union for the treatment of patients with serious skin infections or community acquired pneumonia.

USA – Vein grown from girl's own stem cells transplanted.

USA – Hidden vitamin in milk yields remarkable health benefits - Weill Cornell researchers show tiny vitamin in milk, in high doses, makes mice leaner, faster and stronger.

USA – New report finds biotechnology companies are participating in 39% of all projects in development for new medicines and technologies for neglected diseases.

USA – TriReme Medical receives FDA clearance for expanded matrix of sizes of Chocolate PTA balloon catheter.

USA – New data show investigational compound dapagliflozin demonstrated significant reductions in blood sugar levels when added to sitagliptin in adults with type 2 diabetes at 24 weeks, with results maintained over 48 weeks.

USA – Zalicus successfully completes Phase 1 single ascending dose study with Z944, a novel, oral T-Type Calcium Channel Blocker.

USA – Study provides clues to clinical trial cost savings.

Agilent collaborates with Gachon University to discover biomarkers for cancer and diabetes.

Population Genetics collaborates with Cambridge University to unravel the genetic causes of Asperger Syndrome.

Medicyte GmbH and Reinnervate Ltd to collaborate on development of next generation predictive 3D cell toxicity assays.

Agilent Technologies and Samsung Medical Center to collaborate on clinical research projects.

German Biotech innovator Altona DIAGNOSTICS launches BionexusNexus-Certified regional hub in Malaysia: ADT Biotech Sdn Bhd.

Bosch Packaging Technology has enhanced competences in process technology.

AstraZeneca completes sale of Aptium Oncology assets.

Avacta expands following Aptuscan acquisition.

Angiotech founder joins Union MedTech & Octa Phillip Bioscience Managers global team.

Greenphire appoints John Blakeley Chief Commercial Officer.

INDIA — Asianhhm.com introduces innovative print and digital advertising solutions.

INDONESIA — IMCD acquires leading Indonesian food ingredients distributor Alam Subur.

JAPAN — VITAL Corporation to distribute Imagine Eyes' rtx1™ Adaptive Optics Retinal Camera in Japan.

SINGAPORE — Global threat of multi-drug-resistant Tuberculosis.

SINGAPORE — APAC breeding ground for Anti-bacterial household product innovation.

AUSTRALIA — In defence of the humble ant, champion of biodiversity.

AUSTRALIA — Senz Oncology initiates VAL-1000 clinical trial in patients with acute leukemias.

AUSTRALIA — ABRAXANE^® demonstrates significant improvement in advanced melanoma patients.

AUSTRALIA — Alzheimer's, cancer and rare disease research to benefit from landmark MRC-AstraZeneca compound collaboration.

AUSTRALIA — Nine Sydney researchers to receive funding for biomedical research projects.

AMERICAS — How blind mole rats keep cancer at bay.

AMERICAS — No assembly required for new micro particles.

AMERICAS — Caribbean sardine collapse linked to climate change.

EUROPE — Radioembolization using sir-spheres significantly improves overall survival for patients with inoperable colorectal cancer.

AUSTRALIA – Well-known antibiotic amoxycillin found to be ineffective cough treatment.

AUSTRALIA – Bring the noise: has technology made us scared of silence?

INDIA – Biocon receives marketing authorization for novel biologic itolizumab for psoriasis.

ISRAEL – Aspireo reports Somatoprim Phase Ib interim data.

JAPAN – Daiichi Sankyo and Amplimmune announce strategic alliance to develop AMP-110 therapy for autoimmune disease.

JAPAN – Eisai signs agreement with Epizyme and Roche Molecular Systems to develop companion diagnostic.

THE PHILIPPINES – Asia-Pacific Analysis: The growth of stem-cell therapy.

THE PHILIPPINES – Is the world ready for scientific diplomacy?

UNITED KINGDOM – ARIAD and the U.K. National Cancer Research Institute to collaborate on SPIRIT 3 clinical study.

UNITED KINGDOM – Vision research collaboration on novel treatment for wet age-related macular degeneration.

UNITED STATES – Reducing medical mistakes: Two recently published studies support the use of DNA testing on biopsy samples to prevent misdiagnoses.

UNITED STATES – CoDa Therapeutics reports positive results from Phase IIb Study of NEXAGON® in chronic venous leg ulcers.

UNITED STATES – Inovio Pharmaceuticals to initiate clinical trial for its hepatitis C therapeutic vaccine later this year.

UNITED STATES – Jolt to brain eases pain without drugs.

UNITED STATES – Can a new vaccine prevent colon cancer?

UNITED STATES – Immunovaccine's DPX-Survivac produces sustained, dose related immune responses in Phase I ovarian cancer study.

NCKU researcher develops new use of reservoir sediment.

WILEX Inc. and GeneDiagnostics Inc. enter into partnership for the IVD approval and distribution of the serum HER-2/neu test.

Celsion Corporation and Zhejiang Hisun Pharmaceutical Company enter into technology development agreement for ThermoDox® for the Greater China Territory.

SFDA grants approval for clinical studies to benapenem.

UroFlex now CE-marked; Chinese SFDA approval for Cellvizio.

China National Genebank and Smithsonian's National Museum of Natural History collaborate on biobanking to advance biodiversity research.

New analytical method for uleine alkaloids having anticancer activity.

Zhifei Biological's vaccine approved for clinical test.

EntreMed files new drug clinical trial application for ENMD-2076 with China SFDA to advance global development strategy.

Regeneron and Bayer initiate Phase III trial of EYLEA^® (aflibercept) injection for the treatment of diabetic macular edema in Asia and Russia.

Crystal Pharmatech and Particle Sciences form a US-China pharmaceutical CRO partnership.

SFDA grants approval for clinical studies to Benapenem.

Chinese scientists develop cheap e-notebook for the blind.

China and India catching up in the innovation stakes.

When the West meets the East.

AUSTRALIA – HIV trial validates novel drug mechanism.

SINGAPORE – IBN engineered artificial human livers for drug testing and discovery.

SINGAPORE – Scientists at A*STAR's Genome Institute of Singapore catch evolving germs and cancer cells early.

SINGAPORE – DocDoc and Chatter Buzz Media enter strategic partnership to launch Asia's first healthcare Content Marketing Network.

UNITED STATES – New method developed to expand blood stem cells for bone marrow transplant.

UNITED STATES – Fibrocell/UCLA study on human skin cells yields promising results.

UNITED STATES – Metal stents are effective treatment for blocked bile ducts.

UNITED STATES – Pain drug may prevent preemie lung damage.

UNITED STATES – Gene x3 helps corn grow in acidic soil.

UNITED STATES – Cancer Genetics selected by Gilead Sciences, Inc. to provide clinical trial services for chronic lymphocytic leukemia.

UNITED KINGDOM – DaTSCAN™ SPECT imaging demonstrates impact on the diagnosis of patients with clinically uncertain dementia.

AFRICA – Failing vaccine strategies need to be revamped.

AFRICA – RegeneCure's membrane implant shows 40% accelerated healing time of severe bone fractures.

Can APAC become a global leader in biosimilars?

The State of Biosimilars in 2013: A Progress Report on the Regulatory Environment.

Addressing the Unique Challenges of Running Biosimilar Clinical Trials.

Generics, Supergenerics and the Patent Cliff.

The following topics are under this section:

• Game Changers – Medical Device company leverages on artificial intelligence for robotic surgery
• Epidemiology of Factors associated with Low Muscle Mass in Elderly
• Low Glycaemic Index Foods for Healthier Diets
• Disruptive Technologies in the Tobacco Industry

Objective: This study aims to characterize P and Ta wave of Modified Limb Lead (MLL) Electrocardiogram (ECG) in Normal Sinus Rhythm (NSR) and Atrioventricular Block (AVB).

Methods: ECGs were recorded using MLL configuration from 100 NSR volunteers (mean age 31 years, 35 women) and 20 male AVB patients (mean age 72 years). Amplitudes and durations of P, Ta wave, and PTa Interval (PTaI) were measured, plotted, and analyzed for both the groups.

Results: P-wave amplitudes were larger in AVB, and also P, Ta waves correlated significantly in both groups with higher correlation in AVB (NSR: $r=0.52$; AVB: $r=0.75$). Ta-wave duration ($313\pm 25.1$ms) was longer than P-wave duration ($96\pm 9.3$ms) in AVB patients and was opposite to P-wave polarity in all the leads. PP Interval (PPI) correlated significantly with P wave (NSR: $r=0.27$; AVB: $r=0.78$), Ta wave ($r=0.47$; $r=0.83$), PTaI ($r=0.51$; $r=0.92$), and corrected PTaI ($r=0.61$; $r=0.67$).

Conclusion: P-wave right axis shift leads to the higher P-wave amplitude in AVB which may be due to the advancing age and atrial chamber enlargement. In NSR, the duration of observable Ta wave was longer than P wave, whereas in AVB, the Ta wave duration was 3–3.5 times longer than P wave.

Myocardial infarction is the leading cause of chronic heart failure, an ominous disease entity with a wide prevalence in many countries. The morbidity and mortality of chronic heart failure remains high, despite recent pharmacologic advances and cardiac resynchronization therapy. After acute coronary occlusion, the necrotic area triggers a cascade of pathophysiologic events that may lead to structural and electrophysiological left ventricular remodeling, and eventually to progressive chronic heart failure. Therapeutic strategies targeting the repair of the infarcted myocardium aim at interrupting this vicious cycle and constitute an etiological and, as such, promising approach. However, after the initial enthusiasm accompanying early reports, subsequent preclinical and clinical studies unveiled several challenges associated with cell survival and proliferation, as well as abnormal electrophysiological responses after engraftment. In this chapter, we review the main cell sources that hold promise for clinical use, either alone or combined with growth factors and biomaterials, focusing on the acute and medium-term electrophysiological effects of cardiac regeneration approaches.

This paper summarizes the workshop content on how the integration of large biomolecular and clinical datasets can enhance the field of population health via translational informatics. Large volumes of data present diverse challenges for existing informatics technology, in terms of computational efficiency, modeling effectiveness, statistical computing, discovery algorithms, and heterogeneous data integration. While accumulating large ‘omics measurements on subjects linked with their electronic record remains a challenge, this workshop focuses on non-trivial linkages between large clinical and biomolecular datasets. For example, exposures and clinical datasets can relate through zip codes, while comorbidities and shared molecular mechanisms can relate diseases. Workshop presenters will discuss various methods developed in their respective labs/organizations to overcome the difficulties of combining together such large complex datasets and knowledge to enable the translation to clinical practice for improving health outcomes.

The alumina ceramic is well known to have good biocompatibility and high wear resistance. In a total hip replacement alumina-ceramic head is used combined with polyethylene socket. However, as to a total knee replacement alumina-ceramic component has scarcely used. We have developed new total knee prosthesis with alumina ceramic femoral component designated Bisurface knee prosthesis. Bisurface knee has been designed mainly according to the total condylar prosthesis by the cooperation of Kyoto University and Kyocera Co. Bisurface knee has a unique ball-and-socket joint in the center of the posterior portion of the ftibiofemoral articulation to improve range of motion. In our institute, 233 points were replaced with Bisurface knee fixed with bone cement since 1990 until 1994. We followed 176 joints (135 cases) from 4 to 8 years (average 5.2 years). The average of knee score improved from 47 preoperatively to 81 at follow-up time. The average of flexion angle changed from 119 to 124 degree. Five cases were operated according to infection. Three cases were revised due to instability or a breakage of the patellar peg. At six-year follow-up, the survival rate was 97%. These results showed Bisurface knee with alumina ceramic femoral component has an excellent clinical performance.