In this paper, we first introduce and study the quantum (K1, K2)-Gross Laplacian denoted ΔQG(K1, K2). Then, we prove that ΔQG(K1, K2) is a well defined and linear continuous operator acting on the space of continuous operators and has a quantum stochastic integral. Finally, we give an explicit solution of the quantum heat equation associated with ΔQG(K1, K2). Then, under some positive conditions, we give an integral representation of this solution.