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  • articleNo Access

    EXPERIENCE-CONSISTENT MODELING FOR RADIAL BASIS FUNCTION NEURAL NETWORKS

    We develop a new approach to the design of neural networks, which utilizes a collaborative framework of knowledge-driven experience. In contrast to the "standard" way of developing neural networks, which explicitly exploits experimental data, this approach incorporates a mechanism of knowledge-driven experience. The essence of the proposed scheme of learning is to take advantage of the parameters (connections) of neural networks built in the past for the same phenomenon (which might also exhibit some variability over time or space) for which are interested to construct the network on a basis of currently available data. We establish a conceptual and algorithmic framework to reconcile these two essential sources of information (data and knowledge) in the process of the development of the network. To make a presentation more focused and come up with a detailed quantification of the resulting architecture, we concentrate on the experience-based design of radial basis function neural networks (RBFNNs). We introduce several performance indexes to quantify an effect of utilization of the knowledge residing within the connections of the networks and establish an optimal level of their use. Experimental results are presented for low-dimensional synthetic data and selected datasets available at the Machine Learning Repository.

  • articleNo Access

    Neural Activity Elicited by a Cognitive Task can be Detected in Single-Trials with Simultaneous Intracerebral EEG-fMRI Recordings

    Recent studies have shown that it is feasible to record simultaneously intracerebral EEG (icEEG) and functional magnetic resonance imaging (fMRI) in patients with epilepsy. While it has mainly been used to explore the hemodynamic changes associated with epileptic spikes, this approach could also provide new insight into human cognition. However, the first step is to ensure that cognitive EEG components, that have lower amplitudes than epileptic spikes, can be appropriately detected under fMRI. We compared the high frequency activities (HFA, 50–150Hz) elicited by a reading task in icEEG-only and subsequent icEEG-fMRI in the same patients (n=3), implanted with depth electrodes. Comparable responses were obtained, with 71% of the recording sites that responded during the icEEG-only session also responding during the icEEG-fMRI session. For all the remaining sites, nearby clusters (distant of 7mm or less) also demonstrated significant HFA increase during the icEEG-fMRI session. Significant HFA increases were also observable at the single-trial level in icEEG-fMRI recordings. Our results show that low-amplitude icEEG signal components such as cognitive-induced HFAs can be reliably recorded with simultaneous fMRI. This paves the way for the use of icEEG-fMRI to address various fundamental and clinical issues, notably the identification of the neural correlates of the BOLD signal.

  • chapterOpen Access

    Methods for examining data quality in healthcare integrated data repositories

    This paper summarizes content of the workshop focused on data quality. The first speaker (VH) described data quality infrastructure and data quality evaluation methods currently in place within the Observational Data Science and Informatics (OHDSI) consortium. The speaker described in detail a data quality tool called Achilles Heel and latest development for extending this tool. Interim results of an ongoing Data Quality study within the OHDSI consortium were also presented. The second speaker (MK) described lessons learned and new data quality checks developed by the PEDsNet pediatric research network. The last two speakers (JB, RG) described tools developed by the Sentinel Initiative and University of Utah’s service oriented framework. The workshop discussed at the end and throughout how data quality assessment can be advanced by combining best features of each network.

  • chapterNo Access

    A competency question driven approach to conceptual data model design for digital verification and validation

    This work introduces a data-driven credibility assessment to quantify simulation quality in industrial part re-manufacturing. The framework evaluates the dependability of sources, data, and methodologies, focusing on robustness and uncertainty for data quality and simulation confidence. A conceptual data model, designed using competency questions, maps data requirements, digitalising credibility evaluation and promoting data traceability and accessibility.