In this paper, we define the clique-to-vertex C–v monophonic path, the clique-to-vertex monophonic distance dm(C,v), the clique-to-vertex monophonic eccentricity em2(C), the clique-to-vertex monophonic radius Rm2, and the clique-to-vertex monophonic diameter Dm2, where C is a clique and v a vertex in a connected graph G. We determine these parameters for some standard graphs. We show the inequality among the clique-to-vertex distance, the clique-to-vertex monophonic distance, and the clique-to-vertex detour distance in graphs. Also, it is shown that the clique-to-vertex geodesic, the clique-to-vertex monophonic, and the clique-to-vertex detour are distinct in G. It is shown that Rm2≤Dm2 for every connected graph G and that every two positive integers a and b with 2≤a≤b are realizable as the clique-to-vertex monophonic radius and clique-to-vertex monophonic diameter of some connected graph. Also, it is shown any three positive integers a,b,c with 3≤a≤b≤c are realizable as the clique-to-vertex radius, clique-to-vertex monophonic radius, and clique-to-vertex detour radius of some connected graph and also it is shown that any three positive integers a,b,c with 4≤a≤b≤c are realizable as the clique-to-vertex diameter, clique-to-vertex monophonic diameter, and clique-to-vertex detour diameter of some connected graph. We introduce the clique-to-vertex monophonic center Cm2(G) and the clique-to-vertex monophonic periphery Pm2(G) and it is shown that the clique-to-vertex monophonic center does not lie in a single block of G.