The effective liquid drop model (ELDM) is used to explore the one proton radioactivity of all possible Dysprosium isotopes, and the molecular phase of the di-nuclear system is used to investigate the possible barriers limiting one proton emission. The mass excess values are obtained from [Chin. Phys. C45 (2021) 030003]. The WKB integral is used to evaluate the penetration probability. The half-lives of proton decay are compared to those of other decay modes. The decay chains of 133−135Dy are predicted. The detailed investigations of 133−135Dy show proton radioactivity when 133−135Tb is converted to 132−134Gd with the half-life of order of nanoseconds. Further, these identified proton emitters may find to be useful in the field of diagnosis and radiotherapy.