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In investigating drug addiction and its side effects from a social health point of view, the attention is usually focused on the drug itself. Yet trace amounts of other elements may have side effects no less harmful than addiction itself. The knowledge of these elements can be of help in the cure of drug addiction. The purpose of this study is to determine the trace elements in some drugs by methods of nuclear analysis. In this study, the Proton Induced X-ray Emission (PIXE) and Neutron Activation Analysis (NAA) techniques have been applied to measure the elemental composition and concentration of 55 opium, hashish and ecstasy pill samples. PIXE analysis shows the samples contain various elements including Mg, Al, Si, P, S, Cl, K, Ca, Ti, Fe, Cu, Zn, Rb and Sr.

This short review highlights the author’s group research on modified vitamin B${}_{12}$ derivatives with a peptide backbone as (1) inhibitors of B${}_{12}$-dependent enzymes and as (2) models of cofactor B${}_{12}$-protein complexes.

Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for their analgesic, antipyretic, and anti-inflammatory properties. However, they are also associated with a broad spectrum of hypersensitivity reactions, ranging from mild cutaneous manifestations to severe systemic responses. The complex nature of these reactions and their underlying mechanisms pose challenges in diagnosis and management.

We review the clinical evidence to six distinct clinical phenotypes of NSAID hypersensitivity, including: NSAID-induced urticaria/angioedema or anaphylaxis (SNIUAA), NSAID-exacerbated respiratory disease (NERD), NSAID-exacerbated cutaneous disease (NECD), NSAID-induced urticaria/angioedema (NIUA), food-dependent NSAID-induced hypersensitivity reactions (FDNIH), and selective NSAID-induced delayed reactions (SNIDR). This review aims to provide a comprehensive review of NSAID hypersensitivity reactions based on clinical phenotyping, which can aid in understanding and managing these adverse events.