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It has been shown that when electrons are transferred through chiral molecules, the efficiency of the transfer depends on the electron’s spin and on the handedness of the chiral potential. Hence, chiral molecules serve as spin filters. This effect is termed chiral-induced spin selectivity (CISS). The dependence of the CISS effect on the molecular properties is discussed here as well as some implications of the effect such as in bio-recognition and in the interaction of chiral molecules with ferromagnetic substrates. The role of the CISS effect in various fields is also reviewed.