Sustainable development goals (SDGs) acknowledge the interlinkages between human well-being, economic prosperity, and a healthy environment, and hence, are associated with a wide range of topical issues that include the securities of water, energy, and food (WEF) resources, poverty eradication, economic development, climate change, health, among others. As SDGs are assessed through targets to be achieved by 2030 and monitored through measurable indicators, nexus planning was applied as a transformative approach to monitor and assess progress toward SDG in 2015 and 2018 using South Africa. WEF nexus-related SDGs that were evaluated include Goals 2 (zero hunger), 6 (clean water and sanitation), and 7 (affordable and clean energy). The Analytic Hierarchy Process (AHP) was used to integrate indicators for each of the reference years. Resource management and implementation of WEF-related SDGs improved by 31% (from 0.155 to 0.203) between 2015 and 2018 in South Africa but remained marginally sustainable. The assessment provided an evidence-based support framework for improved and effective management strategies to meet set SDG targets. The connections between the WEF nexus and SDGs strengthen cross-sectoral collaboration among stakeholders, unpack measures for cooperative governance and management, and supporting outcomes that arise from different cross-sectoral interventions. As food production, water provision, and energy accessibility are the major socio-economic and environmental issues currently attracting global attention, the method enhances climate change adaptation.