The system of reaction-diffusion equations with zero-flux and periodic boundary conditions, which has stable steady-states, will induce the cell reproduction pattern by basic analysis of Turing Principle. For models with constant coeffcients, their cell division patterns do not relate to the time factor. Time-related process of cell division is called aberrance of cell division, whose patterns have significant meaning to cancer pathology, especially, for the mechanism of split of cancer cell. Unlike normal cells, cancer cells do not carry on maturing once they have been made. In fact, the cells in a cancer can become even less mature over time. With all the reproducing, it is not surprising that more of the genetic information in the cell can become lost. So the cells become more and more primitive and tend to reproduce more quickly and even more haphazardly. As a result, to explain cancer cells reproduction, one has to study time-related patterns. Therefore, we extend Predator-Prey model with constant coefficients to the model with coefficients to be positive T-periodic functions (we call such a model EP-P model). The goal of this research is to study the pattern formations of EP-P model and simulate the process of tumor forming.
In this paper, by employing the powerful and effective coincidence degree method, we show the existence of T-periodic solutions of ESP-P model in
, where
is a strictly positively invariant region. Furthermore, Floquet theory is provided to show that the T-periodic solution x0(t) of ESP-P model is unique in
and locally uniformly asymptotically stable. This establishes a solid foundation for studying the patterns of EP-P model.