The intervertebral disc is organized with a concentrated proteoglycan solution, the central nucleus pulposus, held within the strong collagen network of the outer annulus fibrosus. The disc exhibits a viscoelastic response when subjected to loads and deformations. Disc degeneration, and/or spondylotic changes that are generally considered to be associated with aging, result in a spinal segment with decreased stiffness. However, in the cervical spine of cerebral palsy patients suffering from athetotic movements of the neck, there is a very early onset of disc degeneration and spondylotic change. Acceleration of disc degeneration has been shown to take place in the spines of animals subjected to excessive extension-flexion of the head and neck. Repetitive torsion of the disc has led to structural regression in in vitro studies using animal spines. Delaminated lamellae and/or disruption of the annulus fibrosus are always recognized in the early stages of the destructive process of the intervertebral disc structure. Disruption of the collagen network may be a result of fatigue failure by repetitive loading, which in turn causes the high tensile stresses in the annulus fibrosus from the development of large hydrostatic pressures within the nucleus pulposus. Loosening of the collagen network may be a key factor leading to the loss of proteoglycans and water, finally inducing the development of disc degeneration. A “degenerated disc” can be induced through pure mechanical fatigue failure of the tissue, as an age-independent degradation of the cartilaginous tissue.